Tubocurarine Flashcards
Adverse effects
.At low doses the stimulant effects predominate while at high doses the reward effects predominate.
Class
A neuromuscular blocker (A nicotinic cholinergic receptor antagonist)
Actions
Tubocurarine binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, the adrenal medulla, neuromuscular junctions, and in the brain.
Mechanism of action
Tubocurarine has two main effects, stimulation and reward. The stimulatory effect occurs mainly in the cortex via the locus ceruleus whilst the reward effect is exerted in the limbic system
Clinical use
Tubocurarine has been superceded by Suxamethonium as the clinically used depolarising neuromuscular blocker
What is Tubocurarine
A neuromuscular blocker (A nicotinic cholinergic receptor antagonist)
what does Tubocurarine bind to
binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, the adrenal medulla, neuromuscular junctions, and in the brain
two main effects of Tubocurarine
stimulation and reward
The stimulatory effect
occurs mainly in the cortex via the locus ceruleus
reward effect
exerted in the limbic system
what happens at low doses
the stimulant effects predominate
what happens at high doses
the reward effects predominate
what has superceeded Tubocurarine as the clinically used depolarising neuromuscular blocker
Suxamethonium
