Edrophonium

Question 1

Class

Answer 1

Anticholinesterase

Question 2

Actions

Answer 2

NMJ: Fasciculation and
increased twitch
tension
Increased peristalsis
Increased secretions
Bradycardia
Bronchoconstriction

Question 3

Mechanism of action

Answer 3

Reversible inhibition of
acetylcholinesterase
reduces the breakdown of
ACh at cholinergic nerve endings which potentiates
neurotransmission

Question 4

Clinical use

Answer 4

Diagnosis of
myasthenia gravis
To confirm that a
proper dose of neostigmine or
pyridostigmine is
being used
Action to short for
therapeutic use

Question 5

Adverse effects

Answer 5

Exacerbates

asthma

Question 6

describe the speed and onset of Edrophonium

Answer 6

rapid-onset, short-acting cholinesterase inhibitor.. Its effect is present within 60 seconds after injection and lasts an average of 10 minutes

Question 7

use of Edrophonium

Answer 7

inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis.

Question 8

mode of action of Edrophonium

Answer 8

prolong the action acetylcholine, via inhibiting acetylcholinesterase at sites of cholinergic transmission.

Question 9

where are Nicotinic acetylcholine receptors are found

Answer 9

throughout the body but especially on the muscle.

Question 10

what happens when the Nicotinic acetylcholine receptors are stumulated

Answer 10

receptors causes to muscle contraction

Question 11

what happens to the Nicotinic acetylcholine receptors when someone is sufferering from myaasthenia gravis

Answer 11

gravis the body’s immune system destroys many of the nicotinic acetylcholine receptors, so the muscle is less responsive to nervous stimulation.

Question 12

how does Edrophonium affect the nerve endings

Answer 12

increases the amount of acetylcholine at the nerve endings, therefore allowing the remaining receptors to function more efficiently.