Ketoconazole

Question 1

Class

Answer 1

Fungal lanosine

demethylase inhibitor

Question 2

Actions

Answer 2

Antifungal

Question 3

Mechanism of action

Answer 3

increases fungal cellular permeability

Question 4

Clinical use

Answer 4

Antifungal agent used
for long periods at
high doses especially
in immunosuppressed
patients

Question 5

Adverse effects

Answer 5

Liver injuries and

adrenal gland problems

Question 6

What does Ketoconazole inhibit

Answer 6

14-α demethylase

Question 7

what is Ketoconazole

Answer 7

: A broad spectrum anti-fungal agent (A Lanosine demethylase inhibitor)

Question 8

what does 14-α demethylase do

Answer 8

, a cytochrome P-450 enzyme which converts lanosterol to ergosterol

Question 9

what is a result of the ergosterol inhibition

Answer 9

causes increased fungal cellular permeability

Question 10

other possible mechanisms for ketoconazole action

Answer 10

1) Inhibition of endogenous respiration.
2) Interaction with membrane phospholipids.
3) Inhibition of yeast transformation to mycelial forms.
4) Inhibition of purine uptake.
5) Impairment of triglyceride and/or phospholipid biosynthesis.