Naloxone

Question 1

Class

Answer 1

Opioid receptor

antagonist

Question 2

Actions

Answer 2

Antagonises the action
of opioid drugs
May cause
hyperalgesia under
conditions such as
stress where
endogenous opioids
may be operative

Question 3

Mechanism of action

Answer 3

Competitive antagonist of
opioids at u, d and k
receptors

Question 4

Adverse effects

Answer 4

Treatment of
respiratory depression
and coma caused by
opioid overdose

Question 5

Clinical use

Answer 5

Free of important
side effects
May cause
withdrawal
symptoms in
opiate addicts

Question 6

What is Naxolaone

Answer 6

An opiate antagonist

Question 7

effects of Naxolaone

Answer 7

prevents or reverses the effects of opioids such as respiratory depression, sedation and hypotension.

Question 8

does a pure narcotic antagonist induce respiratory depression

Answer 8

no

Question 9

how many opiod receptors can Naxolaone antagonise

Answer 9

three, Mu, Kappa, and Gamma

Question 10

what is the strongest binding of to a Naxolaone

Answer 10

the Mu receptor

Question 11

Onset of intravenous Naloxone

Answer 11

is within 2 minutes

Question 12

Onset of subcutaneously or intramuscularly Naloxone

Answer 12

slower

Question 13

Naloxone real life

Answer 13

Naloxone can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.