Ethinylestradiol Flashcards
Class
Oral contraceptive
Actions
Prevention of
pregnancy
Mechanism of action
Suppresses the development of the ovarian follicle by inhibiting follicle stimulating hormone released from anterior pituitary
Clinical use
Prevention of
pregnancy
Adverse effects
May cause weight gain Flushing Mood changes Dizziness Acne Skin pigmentation Risk of thromboembolism
what is Ethinylestradiol
A synthetic derivative of the natural estrogen estradiol
what does Ethinylestradiol interact with
the estrogen receptor (Erα or Erβ) present on female organs, breasts, hypothalamus and pituitary gland
what happens after the ligand binding
Upon ligand binding, the estrogen receptor enters the nucleus, and regulates gene transcription. This leads to an increase in the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppresses follicle-stimulating hormone (FSH) from the anterior pituitary
what happens during menstruation
During menstruation, increased oestradiol levels cause the maturation and release of the egg; as well as the thickening of the uterus lining to allow a fertilized egg to implant
where is Ethinylestradiol mostly made
The hormone is made primarily in the ovaries
what happens to levels of Ethinylestradiol as we age
so levels reduce as women age and
what happens to levels of Ethinylestradiol as we go through menopause
levels decrease significantly during menopause
consequences of too much estradiol
Too much oestradiol has been linked to acne, constipation, loss of sex drive and depression
consequences of too little estradiol
. Conversely too little oestradiol, retards bone growth and development.
consequences of the correct amount of estradiol in men
levels help with bone maintenance, nitric oxide production and brain function.
