Betamethasone

Question 1

Class

Answer 1

Glucocorticoid nuclear
hormone receptor
agonist

Question 2

Actions

Answer 2

Immunosuppressive

Anti-inflammatory

Question 3

Mechanism of action

Answer 3

Inhibit phospholipase A2
which inhibit arachidonic
acid and control synthesis
of prostaglandins and
leukotrienes

Question 4

Clinical use

Answer 4

Relieve skin irritation

such as in eczema

Question 5

Adverse effects

Answer 5

Depression
Pancreatitis
Bloody stools
Hypokalaemia
Hypertension

Question 6

what happens when betamethasone binds to the glucocorticoid receptors

Answer 6

forms a complex, which moves to the nucleus, binds DNA causing alteration in gene transcription.

altered gene transcription causes the production of lipocortins, which inhibits phospholipase A2, and therefore reduces the biosynthesis of prostaglandins and leukotrienes.

corticoid steroid reduce the gene expression of interleukin-1, which is an important inflammaroty cytokine.

Question 7

overall effect of the actions of Betamethasome

Answer 7

The overall effect of both actions drives the anti-inflammatory, immunosuppressive and anti-mitogenic effects of steroids

Question 8

what do you use Betamethasome with if you prescribe it orally

Answer 8

beclomethasone

Question 9

what do you use Betamethosome with if you presiribe it as a glucocorticoid

Answer 9

hydrocortisone or prednisolone.