Rifampicin

Question 1

Class

Answer 1

Antituberculosis drug

Question 2

Actions

Answer 2

Bactericidal for
mycobacteria
Effective against most
gram positive and
many gram-negative
bacteria

Question 3

Mechanism of action

Answer 3

Inhibits bacterial but not
human DNA dependent
RNA polymerase leading
to reduced RNA synthesis
in the bacterial cell

Question 4

Clinical use

Answer 4

Tuberculosis
Leprosy
Meningitis
Brucellosis
Endocarditis
Serious staphylococcal
infections

Question 5

Adverse effects

Answer 5

GIT disturbances
Hepatitis
Rash
Orange tint to
saliva, sweat and
tears
Renal problems
Shock
Thrombocytopeni
c purpura

Question 6

What is Rifampicin

Answer 6

A broad spectrum bactericidal (DNA/RNA polymerase inhibitor)

Question 7

What is a broad spectrum antibiotic

Answer 7

targets both gram-positive and gram-negative organisms

Question 8

how is easily is Rifampicin absorbed and distributed within the body.

Answer 8

very

Question 9

how does Rifampicin act

Answer 9

Its mode of action is via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death

Question 10

what is Rifampcin used to treat and why

Answer 10

Due to the emergence of resistant bacteria, the use of Rifampicin is restricted to Tuberculosis

Question 11

how is Rifampicin metabolised and eliminated

Answer 11

Rifampin is metabolized in the liver and eliminated mainly in bile and, to a limited extent, in urine.