Pyridostigmine Flashcards
Mechanism of action
Reversible inhibition of acetylcholinesterase reduces ACh breakdown which potentiates transmitter action
Adverse effects
May exacerbate
asthma
Class
Anticholinesterase
Actions
Increased peristalsis Increased secretions Bradycardia Bronchoconstriction Decreased intraocular pressure Fasciculation and increased twitch tension
Clinical use
Myasthenia gravis
Post-operative urinary
retention
what is Pyridostigmine
A cholinesterase inhibitor
what is Pyridostigmine biologically
a quaternary amine
what is wrong with Pyridostigmine
it is poorly absorbed in the gut and doesn’t cross the blood-brain barrier.
mode of action of Pyridostigmine
the reversible inhibition of acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase.
what does the inhibition lead to
a reduction in the hydrolysis of acetylcholine, prolonging its effects
what does the reduction of hydrolysis lead to?
increases efficiency of cholinergic transmission in the neuromuscular junction.
why would you use Pyridostigamine instead of neostigmine
slightly longer duration of action
what conditions would you use Pyridostigamine to treat?
myasthenia gravis and to reverse the actions of muscle relaxants
