Tuberculosis Microbiology Of Diagnosis And Management Flashcards
What is the organism that causes tb
Mycobacterium tuberculosis
What features can tb cause in the lungs
Granuloma
What is a granuloma
When macrophages engulf tb
What is a granuloma in the lung known as
Ghon focus
What is a ghon complex
Ghon focus and lymphadenopathy
What is the role of macrophage
Prevent dissemination of tb
What will happen if there is dissemination of tb from the granula
The patient will show symptoms
What can a latent tb infection cause
Secondary tb: reactivation of tb
When is secondary tb likely to occur
When there is a decline in immunity e.g age, hiv
What can a latent infection cause
Nothing: no decrease or decline in the granuloma or immunity
What are the 2 tests that we can carry out in latent tb
Tuberculin skin test (tst)
IGRA test
What is a tuberculin skin test
When you give a subdermal injection of tuberculin and look at the area if there is a raised reaction
When is a tuberculin skin test positive
When there is a reaction
What is a IGRA test
Measurement of white cells release of interferon when exposed to tb particles
Does the TST and IGRA test test for active tb
No