Trypanosoma Flashcards
causative agent, Chagas disease
Trypanosoma cruzi
vector of Chagas disease
Triatomine or reduviid bugs
False about Chagas disease vector
A.Become infected by sucking blood from animals and
humans with circulating parasites
B.May inoculate the organism through its proboscis
into a susceptible human host
C.May also transmit the infective stages in the feces, which enter through breaks in the skin and mucous
membranes
B
infective stage of Trypanosoma cruzi, which is passed in vector’s stool
metacyclic trypomastigote
[Trypanosoma cruzi]
Metacyclic trypomastigotes penetrate various cells at
bite wound site. Inside cells, they transform into
__, which multiply via binary fission
amastigotes
[Trypanosoma cruzi]
Intracellular amastigotes transform into
___, then burst out of the cell and enter
bloodstream
trypomastigotes
[Trypanosoma cruzi]
When triatomine bug takes a blood meal, what devt stage of the parasite does it ingest?
trypomastigote
[Trypanosoma cruzi]
Ingested trypomastigotes @ triatomine bug transform into ___ in the vector’s midgut
epimastigotes
[Trypanosoma cruzi]
Parasites will multiply and differentiate in the ___ nto metacyclic trypoastigtes
hind gut
[Trypanosoma cruzi]
T/F
Amastigotes may also be seen, but in blood
F
tissue biopsy dapat
[Trypanosoma cruzi]
Periorbital soft tissue swelling at site of
inoculation - What is the clinical manif?
Romaña’s Sign
[Trypanosoma cruzi]
Indurated (hard) area of swelling and
redness, located at site of inoculation- What is the clinical manif?
chagoma
Romaña’s Sign & chagoma: present at \_\_ Chagas disease A. acute B. chronic C. both D. none
A
[Trypanosoma cruzi]
Esophagus is thick and does not move
identify clin manif
megaesophagus
nabubuong mga tae, parang mga bato. identify clin manif of Chagas disease
fecaloma
serology has little role in diagnosis of _ Chagas disease A. acute B. chronic C. both D. none
A
big role @ chronic; needing specific IgG antibodies
When is it best to collect CSF from a patient suspected to have Chagas disease?
during disseminton
drugs have little role in treatment of _ Chagas disease A. acute B. chronic C. both D. none
A
causative agent,Human African Trypanosomiasis (HAT)
Trypanosoma brucei
vector (genus + common name) for Human African Trypanosomiasis
genus: Glossina
common name: tsetse fly
[Human African Trypanosomiasis]
Causative agent for this disease @ Central/West Africa
Trypanosoma brucei gambiense:
[Human African Trypanosomiasis]
Causative agent for this disease @ East Africa
Trypanosoma brucei rhodosiense
[Trypanosoma brucei gambiense]
A.primary reservoir
B.human illness caused
C.specific vector
A.primary reservoir - humans
B.human illness caused - chronic sleeping sickness
C.specific vector - tsetse fly (palpalis group)
[Trypanosoma brucei rhodosiense]
A.primary reservoir
B.human illness caused
C.specific vector
A.primary reservoir: antelope/cattle
B.human illness caused: acute sleeping sickness
C.specific vector:tsetse fly (marsitans group)
[Trypanosoma brucei gambiense] Which is false? A. minimal lymphadenopathy B. low parasitemia C. no diagnosis by rodent inoculation
A
prominent dapat
[Trypanosoma brucei rhodosiense] Which is false? A. minimal lymphadenopathy B. low parasitemia C. no diagnosis by rodent inoculation
B
high dapat
[Trypanosoma brucei] Absent in life cycle A. procyclic trypomastigote B. epimastigote C. amastigoite D. metacyclic trypomastigote
C
[Trypanosoma brucei]
Which is false?
A. metacyclic trypomastigote released from feces of tsetse fly
B. metacylic –>bloodstream trypomastigote
C. bloodstream trypomastigotes are ingested by fly
D. bloodstream –>procyclic trypomastigotes @ hind gut of fly
A
metacyclic trypomastigote is injected
[Trypanosoma brucei]
When procyclic trypomastigotes leave hind gut…
A. they go to salivary gland
B. they become metacyclic trypomastigotes
C. none of the above
B
epimastigotes muna, they multiply right after
[Human African Trypanosomiasis]
What is Winterbottom’s sign and in what stage can this be found?
Stage I
enlargement of lymph nodes
[Human African Trypanosomiasis]
characteristics of Stage II - enumerate
Indifference, daytime somnolence, insomnia
at night, changes in speech and gait
Which is typically transmitted in riverbank areas
where people gather for washing, collecting
water, fishing?
A. Trypanosoma brucei rhodosiense
B. Trypanosma brucei gambiense
C. both A and B
D. none of the above
B
Animal to man transmission in parks, areas where game is present A. Trypanosoma brucei rhodosiense B. Trypanosma brucei gambiense C. both A and B D. none of the above
A
