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PH 172 > Trypanosoma > Flashcards

Trypanosoma Flashcards

1
Q

causative agent, Chagas disease

A

Trypanosoma cruzi

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2
Q

vector of Chagas disease

A

Triatomine or reduviid bugs

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3
Q

False about Chagas disease vector
A.Become infected by sucking blood from animals and
humans with circulating parasites
B.May inoculate the organism through its proboscis
into a susceptible human host
C.May also transmit the infective stages in the feces, which enter through breaks in the skin and mucous
membranes

A

B

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4
Q

infective stage of Trypanosoma cruzi, which is passed in vector’s stool

A

metacyclic trypomastigote

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5
Q

[Trypanosoma cruzi]
Metacyclic trypomastigotes penetrate various cells at
bite wound site. Inside cells, they transform into
__, which multiply via binary fission

A

amastigotes

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6
Q

[Trypanosoma cruzi]
Intracellular amastigotes transform into
___, then burst out of the cell and enter
bloodstream

A

trypomastigotes

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7
Q

[Trypanosoma cruzi]

When triatomine bug takes a blood meal, what devt stage of the parasite does it ingest?

A

trypomastigote

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8
Q

[Trypanosoma cruzi]

Ingested trypomastigotes @ triatomine bug transform into ___ in the vector’s midgut

A

epimastigotes

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9
Q

[Trypanosoma cruzi]

Parasites will multiply and differentiate in the ___ nto metacyclic trypoastigtes

A

hind gut

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10
Q

[Trypanosoma cruzi]
T/F
Amastigotes may also be seen, but in blood

A

F

tissue biopsy dapat

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11
Q

[Trypanosoma cruzi]
Periorbital soft tissue swelling at site of
inoculation - What is the clinical manif?

A

Romaña’s Sign

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12
Q

[Trypanosoma cruzi]
Indurated (hard) area of swelling and
redness, located at site of inoculation- What is the clinical manif?

A

chagoma

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13
Q 
Romaña’s Sign & chagoma: present at \_\_ Chagas disease
A. acute
B. chronic
C. both
D. none
A

A

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14
Q

[Trypanosoma cruzi]
Esophagus is thick and does not move
identify clin manif

A

megaesophagus

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15
Q

nabubuong mga tae, parang mga bato. identify clin manif of Chagas disease

A

fecaloma

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16
Q 
serology has little role in diagnosis of _ Chagas disease
A. acute
B. chronic
C. both
D. none
A

A

big role @ chronic; needing specific IgG antibodies

17
Q

When is it best to collect CSF from a patient suspected to have Chagas disease?

A

during disseminton

18
Q 
drugs have little role in treatment of _ Chagas disease
A. acute
B. chronic
C. both
D. none
A

A

19
Q

causative agent,Human African Trypanosomiasis (HAT)

A

Trypanosoma brucei

20
Q

vector (genus + common name) for Human African Trypanosomiasis

A

genus: Glossina

common name: tsetse fly

21
Q

[Human African Trypanosomiasis]

Causative agent for this disease @ Central/West Africa

A

Trypanosoma brucei gambiense:

22
Q

[Human African Trypanosomiasis]

Causative agent for this disease @ East Africa

A

Trypanosoma brucei rhodosiense

23
Q

[Trypanosoma brucei gambiense]
A.primary reservoir
B.human illness caused
C.specific vector

A

A.primary reservoir - humans
B.human illness caused - chronic sleeping sickness
C.specific vector - tsetse fly (palpalis group)

24
Q

[Trypanosoma brucei rhodosiense]
A.primary reservoir
B.human illness caused
C.specific vector

A

A.primary reservoir: antelope/cattle
B.human illness caused: acute sleeping sickness
C.specific vector:tsetse fly (marsitans group)

25
Q 
[Trypanosoma brucei gambiense] 
Which is false?
A. minimal lymphadenopathy
B. low parasitemia
C. no diagnosis by rodent inoculation
A

A

prominent dapat

26
Q 
[Trypanosoma brucei rhodosiense] 
Which is false?
A. minimal lymphadenopathy
B. low parasitemia
C. no diagnosis by rodent inoculation
A

B

high dapat

27
Q 
[Trypanosoma brucei]
Absent in life cycle
A. procyclic trypomastigote
B. epimastigote
C. amastigoite
D. metacyclic trypomastigote
A

C

28
Q

[Trypanosoma brucei]
Which is false?
A. metacyclic trypomastigote released from feces of tsetse fly
B. metacylic –>bloodstream trypomastigote
C. bloodstream trypomastigotes are ingested by fly
D. bloodstream –>procyclic trypomastigotes @ hind gut of fly

A

A

metacyclic trypomastigote is injected

29
Q

[Trypanosoma brucei]
When procyclic trypomastigotes leave hind gut…
A. they go to salivary gland
B. they become metacyclic trypomastigotes
C. none of the above

A

B

epimastigotes muna, they multiply right after

30
Q

[Human African Trypanosomiasis]

What is Winterbottom’s sign and in what stage can this be found?

A

Stage I

enlargement of lymph nodes

31
Q

[Human African Trypanosomiasis]

characteristics of Stage II - enumerate

A

Indifference, daytime somnolence, insomnia

at night, changes in speech and gait

32
Q

Which is typically transmitted in riverbank areas
where people gather for washing, collecting
water, fishing?
A. Trypanosoma brucei rhodosiense
B. Trypanosma brucei gambiense
C. both A and B
D. none of the above

A

B

33
Q 
Animal to man transmission in parks, areas
where game is present
A. Trypanosoma brucei rhodosiense
B. Trypanosma brucei gambiense
C. both A and B
D. none of the above
A

A

PH 172 (25 decks)

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