Trypanosoma Flashcards by Joan Ravalo

causative agent, Chagas disease

Trypanosoma cruzi

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vector of Chagas disease

Triatomine or reduviid bugs

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False about Chagas disease vector
A.Become infected by sucking blood from animals and
humans with circulating parasites
B.May inoculate the organism through its proboscis
into a susceptible human host
C.May also transmit the infective stages in the feces, which enter through breaks in the skin and mucous
membranes

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infective stage of Trypanosoma cruzi, which is passed in vector’s stool

metacyclic trypomastigote

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[Trypanosoma cruzi]
Metacyclic trypomastigotes penetrate various cells at
bite wound site. Inside cells, they transform into
__, which multiply via binary fission

amastigotes

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[Trypanosoma cruzi]
Intracellular amastigotes transform into
___, then burst out of the cell and enter
bloodstream

trypomastigotes

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[Trypanosoma cruzi]

When triatomine bug takes a blood meal, what devt stage of the parasite does it ingest?

trypomastigote

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[Trypanosoma cruzi]

Ingested trypomastigotes @ triatomine bug transform into ___ in the vector’s midgut

epimastigotes

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[Trypanosoma cruzi]

Parasites will multiply and differentiate in the ___ nto metacyclic trypoastigtes

hind gut

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[Trypanosoma cruzi]
T/F
Amastigotes may also be seen, but in blood

tissue biopsy dapat

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[Trypanosoma cruzi]
Periorbital soft tissue swelling at site of
inoculation - What is the clinical manif?

Romaña’s Sign

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[Trypanosoma cruzi]
Indurated (hard) area of swelling and
redness, located at site of inoculation- What is the clinical manif?

chagoma

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Romaña’s Sign &amp; chagoma: present at \_\_ Chagas disease
A. acute
B. chronic
C. both
D. none

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[Trypanosoma cruzi]
Esophagus is thick and does not move
identify clin manif

megaesophagus

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nabubuong mga tae, parang mga bato. identify clin manif of Chagas disease

fecaloma

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serology has little role in diagnosis of _ Chagas disease
A. acute
B. chronic
C. both
D. none

big role @ chronic; needing specific IgG antibodies

When is it best to collect CSF from a patient suspected to have Chagas disease?

during disseminton

drugs have little role in treatment of _ Chagas disease
A. acute
B. chronic
C. both
D. none

causative agent,Human African Trypanosomiasis (HAT)

Trypanosoma brucei

vector (genus + common name) for Human African Trypanosomiasis

genus: Glossina

common name: tsetse fly

[Human African Trypanosomiasis]

Causative agent for this disease @ Central/West Africa

Trypanosoma brucei gambiense:

[Human African Trypanosomiasis]

Causative agent for this disease @ East Africa

Trypanosoma brucei rhodosiense

[Trypanosoma brucei gambiense]
A.primary reservoir
B.human illness caused
C.specific vector

A.primary reservoir - humans
B.human illness caused - chronic sleeping sickness
C.specific vector - tsetse fly (palpalis group)

[Trypanosoma brucei rhodosiense]
A.primary reservoir
B.human illness caused
C.specific vector

A.primary reservoir: antelope/cattle
B.human illness caused: acute sleeping sickness
C.specific vector:tsetse fly (marsitans group)

``` [Trypanosoma brucei gambiense] Which is false? A. minimal lymphadenopathy B. low parasitemia C. no diagnosis by rodent inoculation ```

A prominent dapat

``` [Trypanosoma brucei rhodosiense] Which is false? A. minimal lymphadenopathy B. low parasitemia C. no diagnosis by rodent inoculation ```

B high dapat

``` [Trypanosoma brucei] Absent in life cycle A. procyclic trypomastigote B. epimastigote C. amastigoite D. metacyclic trypomastigote ```

[Trypanosoma brucei] Which is false? A. metacyclic trypomastigote released from feces of tsetse fly B. metacylic -->bloodstream trypomastigote C. bloodstream trypomastigotes are ingested by fly D. bloodstream -->procyclic trypomastigotes @ hind gut of fly

A metacyclic trypomastigote is injected

[Trypanosoma brucei] When procyclic trypomastigotes leave hind gut... A. they go to salivary gland B. they become metacyclic trypomastigotes C. none of the above

B epimastigotes muna, they multiply right after

[Human African Trypanosomiasis] | What is Winterbottom's sign and in what stage can this be found?

Stage I | enlargement of lymph nodes

[Human African Trypanosomiasis] | characteristics of Stage II - enumerate

Indifference, daytime somnolence, insomnia | at night, changes in speech and gait

Which is typically transmitted in riverbank areas where people gather for washing, collecting water, fishing? A. Trypanosoma brucei rhodosiense B. Trypanosma brucei gambiense C. both A and B D. none of the above

``` Animal to man transmission in parks, areas where game is present A. Trypanosoma brucei rhodosiense B. Trypanosma brucei gambiense C. both A and B D. none of the above ```