Journal Reports Flashcards
Title of Group 1’s journal report article
Impact of Six Rounds of Mass Drug Administration on Brugian Filariasis and Soil-Transmitted Helminth Infections in Eastern Indonesia
What drugs were involved in the study presented by Group 1? Basis of dosage was __?
diethylcarbamazine (DEC) combined with albendazole.
dosage basis:age
Study area of Group 1’s journal article
Mainang Village on Alor Island (East Nusa
Tenggara Timor, Indonesia)
False about Sample collection, Group 1’s article
a. Annual surveys (children below 3 years old and
severely ill persons are excluded)
b. 3mL venous blood was collected between 7:00 am
and 11:00 am
c. One labeled stool container per each individual
participating in the blood collection
b. 3mL venous blood was collected between 7:00 am
and 11:00 am
pm dapat, kasi filariasis (note the periodicity!)
Which method was not done in assessment of microfilariae/hookworm eggs & larvae?
a. Harada Mori hatching method
b. direct fecal smear
c. both were not done
b. direct fecal smear
WHO used ___
among school children to stop MDA
Transmission Assessment Survey
(80% baseline to a rate of 6.4%
in 2010, for antibody rate)
Which had higher rebound rate after 34 months of no MDA?
a. Ascaris
b. Trichuris
c. equal
a. Ascaris
Antibody prevalence assessed by Brugia Rapid in the population decreases after MDA but at a slower pace than MF prevalence. True or false?
true
Which is not an objective of the study presented by Group 2?
a. to determine environmental risk factors associated with the rate of E. vermicularis infection in kindergartens
b. to evaluate possibility of airborne transmission of E. vermicularis eggs in Korea
c. to prove which MDA treatment is best for Enterobiasis
c. to prove which MDA treatment is best for Enterobiasis
Which is false?
a. 52 kindergartens were examined in the study
b. cellotape slides were used to examine the inanimate objects frequently in contact with the kindergarten students
c. both are false
A
2 to 3 kindergartens were randomly selected from each of 52 admin districts
Which is false about Group 2’s study?
a. overall egg positive rate: 6.0%
b. max prevalence of enterobiasis in each school: 16.9%
c. more positive cases in public schools than in private schools
C, kasi mas marami sa private
Which was not considered a risk factor in Grp 2’s study?
a. girls
b. habit of thumbsucking
c. number of siblings
d. medication for treatment of pinworm infections
a. girls
infection rate higher in boys
drug combo tested against Trichuris, in group 3’s study
OXANTEL PAMOATE— ALBENDAZOLE
identify
• m-oxyphenol analogue of pyrantel.
• It exhibits high trichuricidal activity.
• when with pamoate, it is effective when given as a single dose of 10 to 20 mg per kilogram of body weight.
oxantel
group 3’s study had a randomised, controlled, double-blind trial. what does double-blind mean?
denoting a test or trial, esp. of a drug, in which any information that may influence the behavior of the tester or the subject is withheld until after the test.
Which treatment is mismatched?
Treatment A:Oxantel Pamoate (20 mg/kg)
Treatment B:Oxantel Pamoate (20 mg/kg) + Albendazole 400 mg
Treatment C:Albendazole 400 mg
Treatment D:Mebendazole 500 mg + Oxantel Pamoate (20 mg/kg)
Treatment D:Mebendazole 500 mg + Oxantel Pamoate (20 mg/kg)
dapat Mebendazole lang
formula for cure rate
cure rate =
(# of children negative for egg after treatment) / (# of children positive before treatment) TIMES 100
formula for egg reduction rate
egg reduction rate=100 x (1-[mean at follow-up / mean at start])
In Group 3’s study, which STH had most number of cases?
Trichuris trichiura
WHO goal to reduce soil-transmitted helminth infection of moderate and high intensity among school-age children to <1% was met in the study. true or false?
false, it was not met; 31.2% at Trichuris, 51.4% at hookworm, 94.4% at Ascaris
Complete the title of Group 5’s journal article
[ ] FOR DETECTION OF MAJOR SOIL-TRANSMITTED HELMINTHS,ASCARIS LUMBRICOIDES, TRICHURIS TRICHIURA, NECATOR AMERICANUS, IN FECAL SAMPLES
TRIPLEX POLYMERASE CHAIN REACTION ASSAY
Objectives of Group 5’s study
[ ], [ ], and [ ] of Multiplex PCR
Sensitivity
Specificity
Validity
In Group 5’s study, 156 stool samples were obtained from __
Thailand
Before the PCR assay itself, ___ was extracted using Favor Prep Tissue ___ Extraction Kit
genomic DNA
DNA concentrations were acquired using ____and stored at -20 degrees Celsius until analyzed
spectrophotometry
Which isolated genes are mismatched?
a. Ascaris- ITS1
b. Trichuris-18S rDNA
c. Hookworm-COI
d. control - hGAPDH
a and c
Sensitivity and specificity of the Multiplex PCR were higher than 80%, true or false? (Kato Katz:standard)
true
multiplex real time PCR using ___probes for diagnosis of 7 intestinal parasites, both highly sensitive and specific
fluorogenic
There is significant diff bet multiplex PCR and Kato Katz, true or false?
false. minimal diff lang
In the study of Group 4, what is the primary parasite being tackled?
hookworm
What is the prevention method in question @ Group 4’s study?
use of footwear
Study setting of group 4’s study
Pemba Island, Zanzibar
true or false: Only the subjects were given shoes
false, everyone in the intervention trial was given shoes
Were the results conclusive in Group 4’s study? Why?
No, because footwear was used in both the control and intervention arm. The difference cannot be fully seen, therefore.
Was the trial in Group 4’s study non-blinded?
yes (cluster randomised non-blinded trial)
which is false?
a. more boys participated than girls
b. average age: 11.3 yrs
c. both are false
A
