Trigger 8: Epigenetics and cancers Flashcards
epigenetic-drven gene inactivation is at least as common as
mutational events which lead to cancers
understanding how genetic and epigenetic alteration drive the initiation nd progression of cancer
will help foster new potential cancer biomarkers and therapeutic opportunities
mutations in the epigenetic writers, readers and eraser
common in cancers
mutations in members of chromatin-remodelling complexes
common in cancer
mutations in the epigenetic regulators offer the cancer cell number of advantages
- require transcriptional programs
- adapt to environmental or therapeutic pressures
which epigenome enzyme are commonly mutated in hematopoietic malignancies
DNMT3A and TET2
DNA hypermethylation leads to
promotor silencing
DNA hypomethylation leads to
genomic instability
deamination of meCpG to TpG leads to
mutation
DNA hypermethylation and hypomethylation and deamination all lead to
cancer
DNA methylation plays a
critical role in carcinogenensis
global hypomethylation
increase genomic instability
de novo promoter hypermethylation leads to silencing of
tumour suppressing genes
de novo promoter hypomethylation may result in activation of
porto-oncogenes
hypermethylation and cancer effects
tumour suppressor genes
name a tumour suppressor gene which is frequently altered in cancers
MLH1
