Treatment of Hemostasis

Question 1

COX-1 to TXA2 platelet inhibitors

Answer 1

Aspirin and NSAIDs

Question 2

ADP antagonist platelet inhibitors

Answer 2

Ticlodipine
Clopidogrel (CYP2C19)

Question 3

Platelet-REceptor Glycoprotein Inhibitors

Answer 3

Abciximab (block gp IIb)

Tirofinban (small glycoprotein inhibiting gp and fibrinogen)

Question 4

Phosphodiesterase inhibitor

Answer 4

Dipyridamole (mainly used in pts w/ prosthetic valves)

Question 5

Antithrombin III accelerator anticoagulant

Answer 5

Heparin (UFH)
Low Molecular Weight Heparins: (Enoxa, Dalte, Tinza-parins)
Fondaparinux (Xa inhibitor)

Question 6

Thrombin Inhibitors

Answer 6

Rudins

Agatroban (treatment for HIT)

Question 7

Vitamin K epoxide reductase inhibitor

Answer 7

Warfarin

Question 8

Oral FXa Inhibitors

Answer 8

-Abans
Apixaban
Rivaroxaban

Question 9

Thombolytic drusg

Answer 9

Streptokinase
Urokinase
Alteplase
Tenecteplase

Question 10

Warfarin Antidote

Answer 10

Vitamin K,

Question 11

Fibrinolytic inhibitor used for bleeding disorder

Answer 11

Aminocaproic acid

Question 12

Protamine Sulfate is antidote for ________ because of its highly cationic charge

Answer 12

Heparin

Question 13

Drugs that increase the metabolism of Wafarin S-isomer

Answer 13

Azoles

Question 14

Drug type that activates warfarin because it displaces albumin and increases serum concentration of warfarin

Answer 14

Sulfonamides

Question 15

Drugs that inhibit activity of Warfarin because of Drug CYP interactions

Answer 15

St Johns wort

Anticonvulsants

Question 16

Reteplase is thrombolytic because it

Answer 16

activates plaminogen to plasmin