Mature B cell Neoplasms: CLL/SLL

Question 1

Characteristic lab findings w/ CLL

Answer 1

Autoimmune hemolytic anemia: warm autoimmune hemolytic anemia
Hypogammaglobulenemia
Paraprotein IgM

Question 2

Classes blood smear findings for CLL

Answer 2

Lymphocytosis and Smudge cells

Question 3

Smudge cells seen w/

Answer 3

CLL/SLL

Question 4

Diffuse infiltrate of small, round lymphocytes that are CD19+, CD20+, CD5+, CD10-, slg + (clonal)

Answer 4

CLL/SLL

Question 5

Weird CD marker associated w/CLL

Answer 5

CD5+

Question 6

Genetic categories of CLL w/ 3 year survival (poor prognosis)

Answer 6

Unmutated: Ig gene rearrangement but no somatic mutation

Question 7

Genetic categories of CLL w/ >7 year survival (intermediate prognosis)

Answer 7

Ig gene rearranged and somatic hypermutation in IgVh

Question 8

Genetic categories of CLL associated w/ trisomy 12

Answer 8

13q deletion, 11q deletion, 17p deletion

Question 9

Transformation of CLL that happens 5-10% of the time and leads to large cell lymphoma, increased LAD, and mean survival of less than 1 year

Answer 9

Richter Transformation

Question 10

Treatment for rapidly progressing CLL

Answer 10

Fludarabine: a purine antagonist

phosphorylated inside the cell, inhibits ribonucleotide reductase and induces apoptosis