Hemostasis Testing and Markers of Pathology

Question 1

Platelet Count normal range is 150,000 to 450,000. traumatic bleeding levels @ and spontaneous bleeding @

Answer 1

traumatic bleeding: 50,000 (surgeries etc)

spontaneous bleeding: 20,000 (no injury, mucous membranes, organs)

Question 2

Causes of Thrombocytopenia

Answer 2

Not making enough (aplastic anemia)

Destroying more (immune thrombocytopenia purpura)

Splenic Sequestration (cirrhosis usually around 150,000)

Hemodilution (Trauma)

Question 3

Bleeding time types

Answer 3

Manual

Automated

Question 4

Manual bleeding time measures what process of clot formation

Answer 4

platelet plug formation

Question 5

Automated bleeding time measures platelet

Answer 5

platelet adhesion, 95% sensitive for vWF disease

Question 6

Prothrombin Time is achieved by adding what to plasma?

Answer 6

Tissue Factor (thromboplastin)
Phospholipid
Calcium

Question 7

Abnormal PTT could be due to defects in extrinsic and common pathways, and could be due to

Answer 7

Liver disease
Vit K deficiency
Warfarin (blocks Vit K epoxide reductase)

Question 8

PTT is measured but is dependent on the ISI particular to certain labs. To account for this difference, the____is an equation that normalizes the PTT w/ ISI values

Answer 8

INR

Question 9

Partial Thromboplastin Time doesn’t add what to the plasma?

Answer 9

Thromboplastin (Tissue factor)

Question 10

Thrombin Time usually around 15 seconds, used to measure any defects in what conversion?

Answer 10

Fibrinogen to fibrin

Question 11

Best test to screen for dysfibrinogenemia?

Answer 11

Thrombin time because it measures fibrinogen to fibrin time

Question 12

what test is used to screen for DIC but has low sensitivity for detecting inherited disorders of increased fibrinolysis

Answer 12

d-dimer

Question 13

What process of coagulation does d-dimer measure?

Answer 13

fibrinolysis