Lymphoid Neoplasms: Follicular Lymphoma and DBCL

Question 1

Follicular Lymphoma staining

Answer 1

Bcl-2

Question 2

Larger cells seen in follicular lymphomas indicate what about the lymphoma?

Answer 2

It has a worse prognosis

Question 3

Where are the neoplastic cells in follicular lymphoma located?

Answer 3

germinal center

Question 4

Nodular infiltrate of small, cleaved lymphocytes w/ admixed large cells, incomplete mantle zone or no mantla zone at all as well as lack of tingible body macrophages allow us to distinguish follicular lymphoma from

Answer 4

reactive lymphoid tissue

Question 5

Genetics of Follicular Lymphoma

Answer 5

t(14;18): overexpression of Bcl-2

Question 6

Diffuse Large B cell lymphoma presents frequently w/ what sort of nodal findings

Answer 6

extranodal presentation

Question 7

Diffuse Large B cell lymphoma is aggressive or not aggressive?

Answer 7

Aggressive

Question 8

CD markers for Diffuse Large B cell lymphoma

Answer 8

CD 19+, CD20+, CD10+/-, CD5-, slg + (clonal)

Question 9

CD markers for Follicular Lymphoma

Answer 9

CD19+, CD20+, CD10+, CD5-, slg + (clonal)

Question 10

Viruses associated with Diffuse Large B cell lymphoma

Answer 10

KSHV, HHV8, EBV