Lymphoid Neoplasms discreet facts

Question 1

Most common pediatric?

Answer 1

precursor B cell

Question 2

Hyperdiploidy is associated with what sort of prognosis??

Answer 2

good prognosis

Question 3

t(12,21) is associated with a ________prognosis

Answer 3

good prognosis

Question 4

Chronic lymphocytic leukemia cell surface markers

Answer 4

CD5 and CD20

Question 5

Most common leukemia?

Answer 5

Chronic lymphocytic leukemia

Question 6

Chronic Lymphocytic Leukemia presents with what histology?

Answer 6

smudge cells, monoclonal immunoglobulin, absolute lymphocytosis

Question 7

Complications of Chronic Lymphocytic Leukemia

Answer 7

Hypogammaglobulinemia
Autoimmune hemolytic anemia
Richter Transformation: diffuse large B-cell lymphoma; (enlarged lymph node or spleen)

Question 8

CLL even though it’s a B cell leukemia expresses what T cell surface marker?

Answer 8

CD5+

Question 9

t(14;18)

Answer 9

Follicular Lymphoma

Question 10

BRAF mutation

Answer 10

Hairy cell leukemia (also in Langerhans Histiocytosis)

Question 11

Trisomy 12

Answer 11

CLL/SLL prognostic marker

Question 12

KSHV/HHV-8 associated B cell lymphoma

Answer 12

Assoc w/ diffuse large B cell lymphomas