Targeted Therapies

Question 1

Non specific biologic agents against cancer (not specific to that particular cancer)

Answer 1

Interferons

Cytokines (Interleukin)

Question 2

Passive Adaptive Biologic Agents (fairly specific)

Answer 2

Immunoglobulins
Monoclonal Antibodies (Mabs)

Question 3

Active Adaptive Bio agents (

Answer 3

Tumor Vaccine: CAR-T

Question 4

Cellular Therapeutics

Answer 4

Modified T Cells

Question 5

Interferons used for

Answer 5

Mycosis Fungoides

Used to be used for: CML, Hair Cell Leukemia, Follicular lymphoma

Question 6

Interleukins and Interferons side effects

Answer 6

fever, myalgias

Question 7

Interleukins used for

Answer 7

IL-2: Renal Cell Carcinoma

Treatment of GVHD

Question 8

Monoclonal Antibody treatment types

Answer 8

Naked example Rituximab

Radioimmuno therapy (seeks out antigen and releases radiation internally)

ADC (Antibody drug conjugate: endocytosed and releases the drug within the cell)

Question 9

HYRituximab used for

Answer 9

B cell lymphoma
CLL
CD20+ ALL
Auto-immune disorders like RA, Lupus, ITP, TTP

Question 10

What must you screen for before administering Rituximab?

Answer 10

Viral reactivation: Hep BV, PML which is a reactivation of the JC virus (polyoma family DNA), Late infections

Question 11

Broad Anti-CD52 Mab

Answer 11

Alemtuzumab, risk of late viral activation

Question 12

Abatacept commonly used for

Answer 12

RA, promotes immune tolerance and anergy

Question 13

Reed Sternberg cells seen in Classical Hodgkin Lymphoma genetic amplification upregulates what immune suppressive molecule that allows it to evade the immune system?

Answer 13

PD-1

Question 14

BiTEs used for

Answer 14

B cell ALL

Question 15

BiTEs used for

Answer 15

B cell ALL

Question 16

CAR-T used for relapsed Hodgkins disease is an example of

Answer 16

Antibody drug conjugate