Lymphoid Neoplasms precursor

Question 1

Acute Lymphoblastic Leukemia is the most common malignancy of childhood and is associated w/ what Trisomy?

Answer 1

Trisomy 21

Question 2

CD and Staining for ALL

Answer 2

Sudan Black-, Myeloperoxidase -

precursor B: CD10+, CD19+, TdT+, slg - (nonclonal)
precursor T: CD 2+, CD3+, CD5+, CD7+, TdT+ slg - (nonclonal)

Question 3

Favorable genetics for Acute Lymphoblastic Leukemia

Answer 3

Hyperdiploidy (51-65 chromosomes)
t(12;21)

also favorable if B cell precursor
4-10years old
<10,000 WBC, no organ involvement

75-85% cure rate

Question 4

Intermediate prognosis of Acute Lymphoblastic Leukemia

Answer 4

t(9;22)

Question 5

Poor prognosis for Acute Lymphoblastic Leukemia

Answer 5

precursor T type
t(4;11)
younger than 2 or older than 10
>100,000 WBC or organ involvement

Question 6

T cell Acute Lymphoblastic Leukemia typically presents as

Answer 6

A Mediastinal Mass