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USMLE > Translocations > Flashcards

Translocations Flashcards

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USMLE® Step 1 flashcards
1
Q

t(9;22)

A 
Philadelphia chromosome
CML
Some ALL (adults, poor prognosis)

Tx = imatinib

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2
Q

t(8;14)

A

Burkitt lymphoma
c-myc activation
Associated with EBV

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3
Q

t(11;14)

A

Mantle cell lymphoma

Cyclin D1 activation (promotes G1 –> S)

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4
Q

t(14;18)

A

Follicular lymphoma

Bcl-2 activation (stabilizes mitochondrial membrane so apoptosis cannot occur)

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5
Q

t(15;17)

A

M3 type of AML
Acute promyelocytic Leukemia

Tx = all-trans retinoic acid (induces maturation of blasts)

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6
Q

t(12;21)

A

B-ALL
Children
Good prognosis

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USMLE (38 decks)

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