Serum Markers Liver/Pancreas Pathology

Question 1

Alkaline phosphatase (ALP)

Answer 1

Obstructive hepatobiliary disease
HCC
Bone disease

Question 2

Aminotransferases (AST/ALT; “liver enzymes”)

Answer 2

Viral hepatitis (ALT>AST)
Alcoholic hepatitis (AST>ALT)

Question 3

Amylase

Answer 3

Actue pancreatitis, mumps

Question 4

Ceruloplasmin

Answer 4

Decreased in Wilson disease

Question 5

Gamma-glutamyl transpeptidase (GGT)

Answer 5

Increased in various liver and biliary diseases (just as ALP can), but not in bone disease; associated with alcohol use

Question 6

Lipase

Answer 6

Acute pancreatitis (most specific)