Oncogenic Microbes and Carcinogens

Question 1

EBV

Answer 1

Burkitt lymphoma
Hodgkin lymphoma
Nasopharyngeal carcinoma
CNS lymphoma (in immunocompromised patients)

Question 2

HBV, HCV

Answer 2

Hepatocellular carcinoma

Question 3

HHV-8 (Kaposi sarcoma-associated herpesvirus)

Answer 3

Kaposi sarcoma

Body cavity fluid B-cell lymphoma

Question 4

HPV

Answer 4

Cervical and penile/anal carcinoma (16, 18), head and neck or oral throat cancer

Question 5

H. pylori

Answer 5

Gastric adenocarcinoma and MALT lymphoma

Question 6

HTLV-1

Answer 6

Adult T-cell leukemia/lymphoma

Question 7

Liver fluke (clonorchis sinesis)

Answer 7

Cholangiocarcinoma

Question 8

Schistosoma haematobium

Answer 8

Bladder cancer (squamous cell)

Question 9

Aflatoxins (Aspergillus)

Answer 9

Liver –> hepatocellular carcinoma

Question 10

Alkylating agents

Answer 10

Blood –> leukemia/lymphoma

Question 11

Aromatic amines (benzidine, 2-naphthylamine)

Answer 11

Bladder –> transitional cell carcinoma

Question 12

Arsenic

Answer 12

Liver –> angiosarcoma
Lung –> lung cancer
Skin –> squamous cell carcinoma

Question 13

Asbestos

Answer 13

Lung –> bronchogenic carcinoma > mesothelioma

Question 14

Carbon tetrachloride

Answer 14

Liver –> centrilobular necrosis, fatty change

Question 15

Cigarette smoke

Answer 15

Bladder –> transitional cell carcinoma
Esophagus –> squamous cell carcinoma/adenocarcinoma
Kidney –> renal cell carcinoma
Larynx –> squamous cell carcinoma
Lung –> squamous cell and small cell carcinoma
Pancreas –> pancreatic adenocarcinoma

Question 16

Ethanol

Answer 16

Liver –> hepatocellular carcinoma

Question 17

Ionizing radiation

Answer 17

Thyroid –> papillary thyroid carcinoma

Question 18

Nitrosamines (smoked foods)

Answer 18

Stomach –> gastric cancer

Question 19

Radon

Answer 19

Lung –> lung cancer (2nd leading cause after cigarette smoke)

Question 20

Vinyl chloride

Answer 20

Liver –> angiosarcoma