Tranexamic Acid

Question 1

Pharmacology and presentation of Tranexamic Acid?

Answer 1

1g:10ml or 500mg:5ml

Antifibrinolytic medicine. It blocks the conversion of plasminogen to plasmin, reducing fibrinolysis (breakdown of blood clots) and bleeding.

Question 2

Indicators of Tranexamic Acid?
PBH

Answer 2

• PPH
• Hypovolaemia from uncontrolled bleeding.
• Any other form of bleeding severe enough to cause hypovolaemia requiring 0.9% sodium chloride to be administered IV.

Question 3

Contraindications of Tranexamic Acid?

Answer 3

• Known severe allergy.
• Trauma when TXA will be administered more than three hours after the time of injury. This appears to increase mortality rates, the cause of which is not clear.

Question 4

Cautions of Tranexamic Acid?

Answer 4

• None

Question 5

Side Effects of Tranexamic Acid?

Answer 5

• None

Question 6

Dosing Regimes of Tranexamic Acid?

Answer 6

Adult IV
- 1g IV for an adult, over 1-2mins, once

Paediatric IV
- 200mg per 10kg IV, over 1-2mins, once

Question 7

Onset and duration of Tranexamic Acid?

Answer 7

Onset:
- 30-60mins

Duration
- 8hrs