Enoxaparin

Question 1

Pharmacology and presentation of Enoxaparin?

Answer 1

100mg in 1ml prefilled syringe

• Low molecular weight heparin (LMWH) anticoagulant.
  Increases the activity of antithrombin Ill (a naturally occurring anticoagulant) causing inhibition of multiple coagulation factors, particularly factor Xa.

Question 2

Indicators of Enoxaparin?

Answer 2

• STEMI in conjunction with fibrinolytic therapy

Question 3

Contraindications of Enoxaparin?

Answer 3

• Known severe allergy

Question 4

Cautions of Enoxaparin?

Answer 4

• Clinically significant bleeding
• At risk of bleeding. (PCI checklist)
• Pregnancy.

Question 5

Side Effects of Enoxaparin?

Answer 5

• Increased bleeding

Question 6

Dosing Regimes of Enoxaparin?

Answer 6

Adult Sub Cut into Abdominal Wall once, with Dosage based on estimated weight and age

• Age less than 75
  • <60kg = 60mg:0.6ml
  • 60-69kg = 70mg:0.7ml
  • 70-79kg = 80mg:0.8ml
  • 80-89kg = 90mg:0.9ml
  • >89kg = 100mg:1ml
• Age 75 years or older
  • <60kg = 45mg:0.45ml
  • 60-69kg = 50mg:0.5ml
  • 70-79kg = 60mg:0.6ml
  • 80-89kg = 70mg:0.7ml
  • >89kg = 75mg:0.75ml

Question 7

Onset and duration of Enoxaparin?

Answer 7

Onset:
- 10-30 minutes

Duration
- 12-24 hours