Ceftriaxone

Question 1

Pharmacology and presentation of Ceftriaxone?

Answer 1

2g powder ampoule

Ceftriaxone is a broad-spectrum cephalosporin antibiotic. That inhibits production of the bacteria cell wall, causing bacteria death

Question 2

Indicators of Ceftriaxone?

Answer 2

• Suspected meningococcal septicaemia

on Meningococcal bacteria death endotoxins release, can cause profound shock

Question 3

Contraindications of Ceftriaxone?

Answer 3

• Anaphylaxis to cephalosporins.

Question 4

Cautions of Ceftriaxone?

Answer 4

• None

Question 5

Side Effects of Ceftriaxone?

Answer 5

• None

Question 6

Dosing Regimes of Ceftriaxone?

Answer 6

Adult

• 2 g IV for an adult, or
• 2 g IM if IV access cannot be immediately obtained
• Nil repeats

Pediatrics

• 300mg:5kg, followed by
• 500mg per 10kg, IV or IM
• Nil repeats

Administration

• 4ml of Saline to ampule
• IV: then dilute to 10ml, discard down to required dose, administer 1-2mins in running line
• IM: undiluted, draw up solution equally into 2 syringes, discard down to required dose, then administer into 2 different IM sites

Question 7

Onset and duration of Ceftriaxone?

Answer 7

Onset:
- 30-60 minutes

Duration
- 24 hours