Tranexamic Acid

Question 1

What classifications is Tranexamic Acid under?

Answer 1

• Hemostatic agent

- Antifibrinolytic agent

Question 2

Explain the pharmacodynamics of Tranexamic Acid

Answer 2

Prevents clot degradation by competing for TPA receptor sites

Question 3

What is the onset timing for Tranexamic Acid

Answer 3

Immediate

Question 4

What is the indication for Tranexamic Acid?

Answer 4

For trauma with signs of shock/hypo perfusion in association with injury suggestive of occult or ongoing bleeding

Question 5

What are the contraindications for Tranexamic Acid?

Answer 5

• Hypersensitivity to tranexamic acid
• Not administered if greater than 3 hours after the injury
• Dialysis
• Age <12 years (PCP) or age <1 year (ACP)

Question 6

List the precautions for Tranexamic Acid

Answer 6

• May potentiate further hypotension if administered too quickly
• IV use only; not to be administered IM, SC

Question 7

List the adverse effects for Tranexamic Acid

Answer 7

May potentiate further hypotension if administered too quickly

Question 8

What is the dosing for Tranexamic Acid

Answer 8

1 g over 10 minutes

Question 9

What is the formatting for TXA administered in a 50mL NS bag?

Answer 9

• 10 gtts drip set

- 1 gtts/s

Question 10

What is the formatting for TXA administered in a 250mL NS bag?

Answer 10

• 10 gtts drip set

- 5 gtts/s (open)