Salbutamol

Question 1

What classifications is Salbutamol under?

Answer 1

• Bronchodilator

- Sympathomimetic

Question 2

Explain the pharmacodynamics of Salbutamol

Answer 2

• Selective β2 stimulation resulting in bronchodilation and some degree of vasodilation
• Some β1 effect – especially with repeated doses
• Little or no α stimulation

Question 3

What is the onset timing for nebulized Salbutamol?

Answer 3

5 minutes

Question 4

What is the peak timing for nebulized Salbutamol?

Answer 4

1.5-2 hours

Question 5

What is the duration for nebulized Salbutamol?

Answer 5

3-8 hours

Question 6

What are the indications for Salbutamol?

Answer 6

• Bronchospasm associated with asthma, bronchitis or emphysema
• Bronchospasm & wheezing secondary to other causes, such as anaphylaxis

Question 7

What are the contraindications for Salbutamol?

Answer 7

• Hypersensitivity

- Hemodynamically significant tachyarrhythmias

Question 8

List the precautions for Salbutamol

Answer 8

• Coronary disease (increased ­MVO2)
• COPD patients with degenerative heart disease
• Diabetes (decreases the effectiveness of insulin)

Question 9

List the adverse effects for Salbutamol

Answer 9

• Restlessness, apprehension, fear, weakness, vertigo
• Nausea and vomiting
• Tachycardia, dysrhythmias
• Paradoxical worsening of respiratory distress, - pulmonary edema
• Sweating, pallor, flushing

Question 10

What is the ADULT dosing for Salbutamol?

Answer 10

5 mg in 5 mL NS or H2O nebulized (with O2 at 6-8 L/min.) - repeat doses back to back prn - watch for signs of toxicity

Question 11

What is the PEDIATRIC dosing for Salbutamol?

Answer 11

• Age < 1 year 2.5 mg via nebulizer

- Age > 1 year 5.0 mg via nebulizer

Question 12

Describe signs of Salbutamol toxicity

Answer 12

H.R > 150 (>200 in pediatric patients) or if severe tremor or ventricular dysrhythmias develop

Question 13

What is the MDI dosing for adult patients?

Answer 13

4 x 100 mcg dose via MDI. Repeat as required. No max dose