Penthrox Flashcards
What classifications is Methoxyflurane under?
Inhaled analgesic
Explain the pharmacodynamics of Methoxyflurane
Methoxyflurane belongs to the halogenated hydrocarbon group of volatile anesthetic agents. Methoxyflurane is the only volatile anesthetic agent with significant analgesic properties at low sub-anesthetic doses
What is the onset timing for Methoxyflurane?
1-3 minutes
What is the duration for Methoxyflurane?
1 hour
How is Methoxyflurane metabolized by the body?
The liver
How is Methoxyflurane excreted from the body?
The lungs
What are the indications for Methoxyflurane?
Moderate to severe pain associated with trauma in adults or interventional medical procedures
What are the contraindications for Methoxyflurane?
- Children <18 y/o
- Inadequate understanding/lack of patient cooperation
- Decreased level of consciousness
- Clinically significant renal impairment
- History of liver dysfunction secondary to previous
halogenated anesthetics - Concurrent use of tetracycline antibiotics
- Personal or family history of malignant hyperthermia
- Muscular dystrophy
- Are pregnant, intending to become pregnant or if you
are breast-feeding
List the precautions for Methoxyflurane
- Supratherapeutic doses have been sown to lead to
serious irreversible nephrotoxicity (follow dosing
limitations) - Maximum daily dose of 6 mL should be used in a
single 48 hour period - A treatment of Penthrox should be limited to a total
dose of 15 ml over one week
What is the dosing for Methoxyflurane?
- 3 mL via inhaler
- Repeat 3 mL dose after 20 minutes
- Total dosage maximum 6 mL
Describe the method of administering Methoxyflurane
Self-administration as needed under direct supervision. One 3 mL bottle to be vaporized in the inhaler. One additional bottle of 3 mL (to a maximum of 6 mL) may be used if needed.
