Acetaminophen Flashcards
What classifications is Acetaminophen under?
- Analgesics
- Antipyretic
Explain the pharmacodynamics of Acetaminophen
Inhibits prostaglandin synthesis. Therapeutic effect include reduction of pain and fever
What is the onset timing for PO Acetaminophen?
30 mins to 1 hour
What is the peak timing for PO Acetaminophen?
1-3 hours
What is the duration for PO Acetaminophen?
3-8 hours
How is Acetaminophen metabolized by the body?
Liver metabolism
How is Acetaminophen excreted from the body?
Renal excretion
What are the indications for Acetaminophen?
- Mild to moderate pain
- Fever (ACP)
What are the contraindications for Acetaminophen?
- Hypersensitivity
- Severe hepatic impairment/active liver disease
List the precautions for Acetaminophen
- Patients with Renal Disease
- Patients with Liver Disease
- Alcoholism
- Chronic malnutrition
- Severe hypovolemia
- Hepatotoxic metabolites
List the adverse effects for Acetaminophen
- Hepatoxicity
- Rash
- Urticaria (Hives)
- Constipation
What is the ADULT dosing for Acetaminophen?
500-1000 mg PO
- May repeat once after 4 hours
- Maximum 4 grams in 24 hours or 1-2 grams in 24 hours if liver cirrhosis
Can Acetaminophen be used concurrently with ibuprofen for analgesia?
Yes, yes it can.
Can PCPs use Acetaminophen as an anti-pyretic?
No.
What is the PEDIATRIC dosing for Acetaminophen?
<30 kg: 15 mg/kg (liquid form)
30-50 kg: 500 mg PO (liquid or tablet, dependent on patient ability)
> 50 kg: 500 - 1000 mg PO
May repeat once after 4 hours (maximum 75 mg/kg or 1 gram in 24 hours from all sources)
- Do not exceed 5 doses/24 hours in pediatric patients ≤12 yrs
- May be used concurrently with ibuprofen for analgesia.
