Ibuprofen

Question 1

What classifications is Ibuprofen under?

Answer 1

• Analgesics
• Antipyretic
• Non-steroidal anti-inflammatory (NSAID)

Question 2

Explain the pharmacodynamics of Ibuprofen

Answer 2

Inhibits prostaglandin synthesis. Therapeutic effect include reduction of pain, inflammation, and fever.

Question 3

How is Ibuprofen metabolized by the body?

Answer 3

Liver

Question 4

How is Ibuprofen excreted from the body?

Answer 4

Renally

Question 5

What are the indications for Ibuprofen?

Answer 5

• Mild to moderate pain

- Fever

Question 6

What are the contraindications for Ibuprofen?

Answer 6

• Allergy to ibuprofen or other non-steroidal anti-inflammatory (NSAIDS) agents.
• Active GI bleed or ulcers
• Pregnancy: First, Second, and Third Trimester
• Perioperative pain from Coronary Artery Bypass Graft (CABG) surgery

Question 7

List the precautions for Ibuprofen

Answer 7

• Patients with Renal Disease
• Patients with Liver Disease
• Patients with Cardiovascular Disease (CVD)
• Recent Surgery

Question 8

List the adverse effects for Ibuprofen

Answer 8

• Anaphylaxis
• GI Bleeding
• Dyspepsia, Nausea, Vomiting, Constipation
• Headache
• Prolonged Bleeding Time
• Stevens-Johnsons syndrome
• Rash
• Renal Failure

Question 9

What is the ADULT dosing for Ibuprofen?

Answer 9

PO (Analgesic/Antipyretic): 300-400 mg PO
- Every 4-6 hrs
- Max: 1200 mg/day
- Only ACP and above may administer ibuprofen as an
antipyretic

Question 10

What is the peak timing for PO Ibuprofen when being used as an Analgesic?

Answer 10

1-2 hours

Question 11

Can PCPs use Ibuprofen as an anti-pyretic?

Answer 11

Nope

Question 12

What is the PEDIATRIC dosing for Ibuprofen?

Answer 12

PO Analgesic:
- (Infants and Children) 10 mg/kg PO
- Repeat once after 6 hours (maximum 40mg/kg in 24
hours from all sources)
PO Antipyretic: (Children 6 mo–12 yr)
- Only ACP and above may administer ibuprofen as
an antipyretic
- 5 mg/kg for temperature 39 C), may be repeated q
4–6 hr
- 10 mg/kg for higher temperatures, may be repeated
q 4–6 hr
- Do not exceed 40 mg/kg/day from all sources
- Cystic fibrosis (unlabeled): 20–30 mg/kg/day divided twice daily
PO NSAID: (Children 6 mo– 12 yr)
- 30– 50 mg/kg/day in 3–4 divided doses
- Maximum dose: 2.4 g/day.

Question 13

What is the maximum dose of Ibuprofen an ADULT PT can be given?

Answer 13

Max: 1200 mg/day

Question 14

What is the maximum dose of Ibuprofen a PEDIATRIC PT can be given?

Answer 14

maximum 40mg/kg in 24 hours from all sources

Question 15

How is Ibuprofen absorbed by the body?

Answer 15

80% GI tract absorption