DinenhyDRINATE Flashcards
What classifications does DimenhyDRINATE fall under?
- Antiemetic
- Antihistamine
- Anticholinergic
- Anti-vertigo
Explain the pharmacodynamics of DimenhyDRINATE
- Inhibits vestibular (labyrinth) stimulation from motion
- Inhibits cholinergic stimulation in vestibular and reticular systems, which may cause nausea and vomiting
What is the onset timing for IV DimenhyDRINATE?
Almost immediate
What is the duration for IV DimenhyDRINATE?
6 to 6 hours
How is DimenhyDRINATE metabolized by the body?
Liver metabolism
How is DimenhyDRINATE excreted from the body?
Excreted in urine
What are the indications for DimenhyDRINATE?
- Prevention or control of nausea caused by administration of narcotics and/or motion sickness
- Relief of moderate to severe nausea and vomiting (if more appropriate antiemetic not available)
What are the contraindications for DimenhyDRINATE?
Known sensitivity to DimenhyDRINATE, DyphenhyDRAMINE or caffeine derivatives
List the precautions for DimenhyDRINATE
- Increased intraocular pressure / glaucoma
- Prostatic hyperplasia and urinary obstruction
- Cardiovascular disease (ischemic heart disease and hypertension)
- Asthma/COPD
- Elderly due to anticholinergic effect
- Caution in pregnant women (risk/benefits
What is the ADULT dosing for DimenhyDRINATE?
- 25 to 50 mg
- 12.5 mg in the frail elderly patient
Repeat once if required
What is the PEDIATRIC dosing for DimenhyDRINATE?
- Max single dose 1.25 mg/kg
- Max total daily dose 5 mg/kg/day (2-6 years = 75 mg/day; 6-12 years = 150 mg/day)
What are the methods of administration for DimenhyDRINATE?
- IM given as a direct injection
- IV diluted with normal saline
- Given over 1 minute (25 mg/min maximum)
List the CNS side effects for DimenhyDRINATE
- Drowsiness
- Ataxia (overdose)
- Disorientation (overdose)
- Excitement
- Dizziness
- Nausea
- Lassitude
List the CVS side effects for DimenhyDRINATE
- Hypotension
- Palpitations
- Bradycardia/tachycardia
List the GI side effect for DimenhyDRINATE
- Dry mouth
