Aspirin Flashcards
What classifications is Aspirin under?
- Antiplatelet
- Antithrombotic
- Aspirin also falls under many other functional classifications
Explain the pharmacodynamics of Aspirin
Inhibits the formation of thromboxane A2 which is a potent platelet aggregate and vasoconstrictor
What is the onset timing for PO Aspirin?
1 hour, 20 minutes if chewed
What is the peak timing for PO Aspirin?
1 to 2 hours
What is the duration for PO Aspirin?
4 to 6 hours; platelet inhibitory effects last the lifetime of the platelet (~10 days)
How is Aspirin metabolized by the body?
Liver metabolism
How is Aspirin excreted from the body?
Renal excretion
What are the indications for Aspirin?
Chest pain or atypical symptoms consistent with cardiac ischemia/AMI
What are the contraindications of Aspirin?
- Allergy to aspirin or other non-steroidal anti-inflammatory (NSAIDS) agents. This includes many non-aspirin/non-Tylenol pain relievers such as Advil
- Asthma (see special notes)
- Recent head injury, stroke or acute bleeding (significant) of any kind
- Pediatric patients with viral symptoms
List the precautions for Aspirin
- Recent internal bleeding (within last 3 months)
- Known bleeding diseases
- Patients currently taking anticoagulant agent(s)
- Recent surgery
- Possibility of pregnancy
What is the dosing for Aspirin?
160 mg (Ensure they chew it before swallowing)
Can Aspirin be used in PEDIATRIC PTs?
- Contraindicated in pediatric patients with viral illness.
Chest pain in children is unlikely to be ischemic in nature therefore ASA not indicated unless rare specific ischemic cardiac history
What has Aspirin be linked to in PEDIATRIC PTs?
Reye’s syndrome in children with a viral history such as chicken pox, or influenza.
Is Aspirin contraindicated in asthmatic PTs?
Aspirin IS contraindicated in patients who have experienced an exacerbation of their asthma after taking ASA
