Tramadol

Question 1

What is the MOA of Tramadol?

Answer 1

Tramadol is an analgesic

Opiate receptor stimulation and inhibition of re-uptake of noradrenaline and serotonin

Question 2

What are the indications for tramadol?

Answer 2

Moderate pain usually in combo with paracetamol and ibuprofen
May be adiministered for severe pain if no Para/ICP available b/c tramadol wont

Question 3

Contras/Cautions/Pregnancy and tramadol?

Answer 3

Contras:
Known severe allergy
Age less than 12 years

Cautions:
Tramadol within last 4 hours (proceed if does not exceed total dose stated in CPG’s)
Abdo pain (sig GI illness, PO meds normally withheld)
Age >= 75 esp if hx confusion or dementia
Confusion. (anticholinergic /neurotransmitter blocking effect may worsen confusion)

Pregnancy - tramadol should usually be withheld/stop breastfeeding if admin

Question 4

What dosage should be used with Tramadol?

Answer 4

50 mg for paitient 12 yr or older

Question 5

What are common adverse effects of Tramadol?

Answer 5

Nausea/vomiting
Lightheadedness/feeling unusual
Sedation
Dry mouth

Question 6

Onset /duration of Tramadol?

Answer 6

30-60min onset

4-8 hr duration

Question 7

Should tramadol be given for Mycardial ischemia?

Answer 7

Not indicated