Entonox

Question 1

What is the MOA for Entonox?

Answer 1

MOA of Nitrous Oxide poor understood

• suppresses CNS impulses
• bocks N-methyl-d-asparate (NMDA) receptors
• Stimulation of gamma amino-butyric acid (GABA) receptors

Question 2

What is the indication for Entonox?

Answer 2

Moderate to severe pain, usually in addition to other measures

Question 3

What are the contraindications for Entonox?

Answer 3

• known severe allergy
• Unable to obey commands
• Suspected pnuemothorax
• Suspected bowel obstruction
• SCUBA diving in last 24 hours
• SCUBA diving related emergency

Question 4

What are the cautions for Entonox?

Answer 4

• Administration within a confined space (ambulance is not a considered a confined space)
• repeated use associated with psychological dependence, bone marrow suppression and neurological disorders

Question 5

What are adverse effects of Entonox?

Answer 5

• Sedation/light headedness
• Euphoria
• Metallic taste