Glucagon

Question 1

What is the MOA for Glucagon?

Answer 1

Increases blood glucose level by stimulating glycogenolysis mainly within the liver

Question 2

What are the indications for Glucagon?

Answer 2

Hypoglycaemia when patient cannot swallow food/glucose gel and where IV access cannot be obtained

Question 3

What are the contraindications and cautions for Glucagon?

Answer 3

Contra: Known severe allergy
Cautions: None

Question 4

Can Glucagon be used in pregnancy or while breastfeeding?

Answer 4

Safe and should be administered if indicated

Question 5

What doseage of Glucagon should be administered?

Answer 5

*1 mg IM for an adult or child aged five and over
*0.5mg IM < 5 years old
DO NOT REPEAT DOSE

Question 6

What is the onset and duration of effect of Glucagon?

Answer 6

5-10 min onset, 15-60 min duration

Question 7

What are the adverse effects of glucagon?

Answer 7

None

Question 8

When might glucagon be ineffective in a hypoglycaemic patient?

Answer 8

If glycogen stores are depleted, it will not be effective.
e.g. strenuous exercise, has not eaten >12hrs, adrenal insufficiency, chronic hypoglycaemia, alcohol induced hypoglycaemia

Question 9

What should you give a patient after giving glucagon?

Answer 9

If competent, you must give patient some food to replace depleted glycogen reserves