Ondansetron

Question 1

What is the MOA for Ondansetron?

Answer 1

Ondansetron is an antiemitic

It blocks serotonin recptors in brain and GI tract reducing nausea and vomiting

Question 2

What are the indications for ondansetron?

Answer 2

Clinically significant nausea or vomiting

Question 3

Contraindications/cautions/pregnancy for ondansetron?

Answer 3

1. Known severe allergy
2. Age less 1 year

Caution: known prolongued QT syndrome, it may prolongue the interval if administer

Safety not demonstrated with pregnancy. May be administered if vomiting nausea is severe, no breastfeeding

Question 4

What is the appropriate dosage for ondansetron?

Answer 4

8mg PO >/= 12 years

see paediatric tables for children

Question 5

What is the onset and duration of ondansetron?

Answer 5

PO 10-20mins, duration 4-8 hrs