Toxicology Flashcards
What is the treatment for acetaminophen toxicity?
SamE vs N-acetylcysteine
Strychnine toxicity MOA
Inhibits glycine which makes it easier for neurons to fire AP leading to tetanus
Poodle with 24 history of vomiting, anorexia, lethargy. Bloodwork shows elevated ALT, ALP, GGT, Tbil, low albumin, NORMAL BG and BUN. What is the most likely diagnosis?
Aflatoxin
Cyanide toxicity MOA and what does it not respond to?
Inhibits ATP production in the mitochondria, not responsive to O2 supplementation.
Inhibition cytochrome oxidase.
Carbon monoxide toxicity MOA
Binds Hg with high affinity which prevents binding of O2.
Which toxin increases osmolarity?
Ethylene glycol
Osmolar gap = calculated - measured
Difference in unmeasured osmoles
Mechanism of action of botulinum toxin
Inhibits Ach from axon causing flaccid paralysis
Inhibition of acetylcholine release from the presynaptic membrane.
Treatment of lead toxicity?
Bloodwork findings with lead toxicity?
Tx: CaEDTA?
Nucleated RBC and non regenerative anemia
What increases first with rodenticide toxicity?
PIVKA
Signs of castor bean toxicity?
GI
MOA of cardiac glycosides?
NaKATPase inhibition
MOA of organophosphate toxicity?
Inhibition of acetylcholinesterase
SLUDD signs
Treatment for intoxication to amanita mushrooms?
Silybin
Which organ is affected by blue green algae toxicosis?
Liver
Clinical signs of marijuana toxicity.
CNS depression, disorientation, ataxia, glassy eyes, mydriasis, recumbency, hypothermia, bradycardia, behavioral changes. Urine dribbling/incontinence. Fly-biting in cats. Less commonly, GI upset, stupor, and seizures
