Pharmacology

Question 1

Doxycycline MOA

Answer 1

30s ribosomal subunit

Question 2

Cisapride MOA

Answer 2

5HT-4 agonist

Question 3

Gabapentin MOA

Answer 3

Inhibition of voltage-gated Ca channels

Question 4

Ondansetron MOA

Answer 4

5HT-3 antagonist

Question 5

Cyclosporine MOA

Answer 5

Binds and form complex with cyclophilin which inhibits calcineurin/NFAT (nuclear activated T cells) which decreases T-cell inflammatory cytokine production IL-2

Question 6

Enrofloxacin MOA

Answer 6

DNA gyrase inhibitor

Topo II and DNA gyrase

Question 7

Location of nephrotoxicity for gentamicin

Answer 7

Proximal tubule

Question 8

Aspirin MOA

Answer 8

COX inhibition (irreversible)

Question 9

Drug that decrease CSF production?

Answer 9

Omeprazole - questionable

Question 10

Effects of diuretics:

Answer 10

Loop - thick ascending limb loop of helm
Thiazide - distal convoluted tubule
Spiro/K-sparing - collecting duct

Question 11

Side effect of misoprostol?

Answer 11

Abortion in humans

Question 12

You give diazepam to a boxer and it starts to have neurological signs, what to you give it?

Answer 12

Flumazenil (reversal)

Question 13

Which antibiotics penetrate prostate?

Answer 13

TMS, chloramphenicol and enrofloxacin

Question 14

What do you need to determine drug dose in an animal?

Answer 14

Volume of distribution

Question 15

Which drug can cause clinical signs of hypothyroidism?

Answer 15

TMS

Question 16

Chloramphenicol toxicity?

Answer 16

Bone marrow

Question 17

Pred:Dex ratio

Answer 17

7

Question 18

Cox specificity for firocoxib?

Answer 18

COX-2

Question 19

What is phase II drug metabolism?

Answer 19

Glucuronidation

Question 20

Diazoxide MOA?

Answer 20

Inhibition of closure of ATP-dependent K+ channels in beta-cells which inhibits depolarization and thus inhibits insulin release.

Question 21

Oclacitinib side effects (and MOA)?

What is Oclatinib?

Answer 21

Oclatinib is apoquel
Indication: pruritus and atopic dermatitis
MOA: synthetic Janus Kinase (JAK) inhibitor
SE: Diarrhea

Question 22

Propantheline MOA?

Answer 22

?

Antimuscarinic

Question 23

Proin MOA

What is Proin?

Answer 23

Phenylpropanolamine - alpha agonist at the urethral sphincter (little bit beta too)

Question 24

What is a way to decrease antibiotic resistance?

Answer 24

Changing to narrow spectrum after C&S (vs decreased duration/increased dose)

Question 25

Lidocaine MOA

Answer 25

NA channel blocker

Question 26

Amoxicillin MOA

Answer 26

Target cell wall synthesis, inhibit PG cross linking by competitively inhibiting transpeptidase enzyme

Question 27

Clopidogrel MOA

Answer 27

Irreversible binding to P2Y12 receptor - inhibits platelets aggregation

Question 28

First pass metabolism

Answer 28

Rectal administration

Question 29

How to treat ivermectin toxicity?

Answer 29

IV lipids

Question 30

What is an antibiotic that concentrates in urine?

Answer 30

Ampi

Question 31

Erythromycin MOA

Answer 31

50s

Question 32

Heparin MOA

Answer 32

Antithrombin (potentiates)

Question 33

Leflunomide MOA

Answer 33

Reversible inhibition of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH), inhibits de novo synthesis of pyrimidines

Question 34

Capromorelin MOA?

Answer 34

Ghrelin agonist

Question 35

What is the enzyme that is inhibited by trilostane?

Answer 35

3β-hydroxysteroid dehydrogenase (HSD3B2)

Question 36

What would you give to a patient with a positive atropine response test?

Answer 36

Propantheline

Question 37

Sulfonamide MOA?

Answer 37

Inhibit folate synthesis

Question 38

Baytril MOA

Answer 38

Topo II and DNA gyrase

Question 39

What is neostigmine?

Answer 39

``` Cholinesterase inhibitor (anticholinesterase) to treat myasthenia gravis More potent and shorter acting than pyridostigmine ```

Question 40

What would you treat a polycythemia (HCT 75%) patient with?

Answer 40

Hydroxyurea

Question 41

What is orlistat and what is its mechanism of action?

Answer 41

Weight loss mechanism Decreased absorption of lipids from intestinal tract and increased satiety Reversible inhibition of the gastric and pancreatic lipases so basically you don't digest fat.

Question 42

Maropitant MOA

Answer 42

NK-1 antagonist

Question 43

Which medication can be used as a pro kinetic thanks to its acetylcholinesterase activity?

Answer 43

Neostigmine

Question 44

What makes glargine long acting?

Answer 44

Formation of crystals in the SQ

Question 45

Why is the lipid form of amphotericin B less nephrotoxic?

Answer 45

Less interaction with cholesterol in kidneys