Toxicity Treatments Flashcards

1
Q

Acetaminophen

A
N-Acetylcysteine
Replenish Glutathione (GSG)
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2
Q

AChE Inhibitors

Organophosphates

A

Atropine: Central and Peripheral
Pralidoxime: Peripheral

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3
Q

Antimuscarinic/Anticholinergic Agents

A

Physostigmine

Control Hyperthermia

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4
Q

Arsenic

A

Dimercaprol

Succimer

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5
Q

Benzodiazepenes

A

Flumazenil

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6
Q

Beta-Blockers

A

Atropine

Glucagon

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7
Q

Carbon Monoxide

A

100% O2

Hyperbaric O2

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8
Q

Copper

A

Penicillamine
Trientine

(Think Wilson’s)

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9
Q

Cyanide

A

Nitrite + Thiosulfate

Hydroxycobalamin

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10
Q

Digitalis (Digoxin)

A

Anti-dig Fab fragments

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11
Q

Heaparin

A

Protamine Sulfate

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12
Q

Iron

A

Deferoxamine
Derasirox
Deferiprone

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13
Q

Lead

A

EDTA
Dimercaprol
Succimer
Penicillamine

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14
Q

Mercury

A

Dimercaprol

Succimer

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15
Q

Methanol or Ethylene Glycol

A
  1. Fomepizole
  2. Ethanol
  3. Dialysis
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16
Q

Methemoglobin

A

Methylene blue

Vitamin C

17
Q

Opioids

A

Naloxone

18
Q

Salicylates

A

NaHCO3 (Alkalinize urine)

Dialysis

19
Q

TCA’s

A

NaHCO3

20
Q

Warfarin

A
Vitamin K (Delayed)
FFP (Immediate)
21
Q

Neuroleptic Malignant Syndrome

A

Dantrolene

22
Q

Serotonin Syndrome

A

Cyproheptadine

23
Q

Tetrodotoxin MOA

A

Pufferfish
Binds fast voltage-gated Na+ channels in cardiac/nerve tissue - preventing depolarization

TX: Supportive

24
Q

Ciguatoxin

A

Reef fish - Barracuda, Snapper, Moray eel
Opens Na+ channels causing depolarization

TX: Supportive

25
Q

Spoiled dark-meat fish - Tuna, Mahi mani, Mackerel, Bonito

Scombroid poisoning

A

Bacterial Histidine decarboxylase converts Histidine to HISTAMINE
Looks like Anaphylaxis

Frequently misdiagnosed as fish allergy
TX: Antihistamines, Albuterol and Epinephrine if needed