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HIGH YIELD > Oncogenes/Tumor Suppressor Genes p.218 > Flashcards

Oncogenes/Tumor Suppressor Genes p.218 Flashcards

1
Q

ALK

A

Oncogene
Receptor Tyrosine Kinase

Lung Adenocarcinoma

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2
Q

BCR-ABL

A

Oncogene
Tyrosine Kinase

CML, ALL

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3
Q

BCL-2

A

Oncogene
Antiapoptotoic Molecule

Follicular and Diffuse Large B Cell Lymphomas

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4
Q

BRAF

A

Oncogene
Serine/Threonine Kinase

Melanoma
Non-Hodgkin Lymphoma
Papillary Thyroid Carcinoma

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5
Q

c-KIT

A

Oncogene
Cytokine Receptor

Gastrointestinal Stromal Tumor (GIST)
TX: Imatinib

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6
Q

c-MYC

A

Oncogene
Transcription Factor

Burkitt Lymphoma

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7
Q

HER2/neu

A

Oncogene
Receptor Tyrosine Kinase

Breast and Gastric Carcinomas

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8
Q

JAK2

A

Oncogene
Tyrosine Kinase

Chronic Myeloproliferative Disorder

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9
Q

KRAS

A

Oncogene
GTPase

Colon Cancer
Lung Cancer
Pancreatic Cancer

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10
Q

MYCL1

A

Oncogene
TF

Lung Tumor

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11
Q

MYCN

A

Oncogene
TF

Neuroblastoma

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12
Q

RET

A

Oncogene
Receptor Tyrosine Kinase

MEN2A and 2B
Medullary Thyroid Cancer
Chromosome 10

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13
Q

APC

A

Tumor Suppressor Gene
Negative Regulator of Beta-Catenin/WNT Pathway

Colorectal Cancer (associated with FAP)

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14
Q

BRCA1/BRCA2

A

Tumor Suppressor Gene
DNA Repair Protein

Breast, Ovarian Carcinoma
Pancreatic Carcinoma

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15
Q

CDKN2A

A

Tumor Suppressor Gene
p16 - Blocks G1 -> S phase

Melanoma
Pancreatic Cancer

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16
Q

DCC

A

Tumor Suppressor Gene

DCC = Deleted in Colon Cancer

17
Q

DPC4/SMAD4

A

Tumor Suppressor Gene

DPC = Deleted in Pancreatic Cancer

18
Q

MEN1

A

Tumor Suppressor Gene
Menin

MEN1

19
Q

NF1

A

Tumor Suppressor Gene
Neurofibromin (Ras GTPase activating protein)

NF1

20
Q

NF2

A

Tumor Suppressor Gene
Merlin (Schwannomin protein)

NF2

21
Q

PTEN

A

Tumor Suppressor Gene
Tyrosine Phosphatase of PIP3 (eg. Protein Kinase B AKT activation)

Breast Cancer
Prostate Cancer
Endometrial Cancer

22
Q

Rb

A

Tumor Suppressor Gene
Inhibits E2F - Blocks G1 -> S Phase

Retinoblastoma
Osteosarcoma

23
Q

Tp53

A

Tumor Suppressor Gene
p53 - Activates p21. Blocks G1 -> S Phase

LiFraumeni Syndrome
SBLA Cancers - Sarcoma, Breast, Leukemia, Adrenal Gland

24
Q

TSC1

A 
Tumor Suppressor Gene
Hamartin protein (Chromosome 9)

Tuberous Sclerosis

25
Q

TSC2

A 
Tumor Suppressor Gene
Tuberin protein (Chromosome 16)

Tuberous Sclerosis

26
Q

VHL

A

Tumor Suppressor Gene
Inhibits Hypoxia Inducible Factor 1a

von Hippel-Lindau Disease

27
Q

WT1

A

Tumor Suppressor Gene
Transcription factor that regulates urogenital development

Wilms Tumor (Nephroblastoma)

28
Q

PDGFB

A

Astrocytoma

Oncogene

29
Q

Cyclin D1

A

Mantle Cell Lymphoma
Oncogene

t(11;14)

30
Q

CDK4

A

Melanoma

Oncogene

HIGH YIELD (21 decks)

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