Serum Tumor Markers p.220 p.44 and Hypothalamic/Thalamic Nuclei p. 466-468 Flashcards
CA 15-3
CA 27-29
Breast Cancer
CA 19-9
Pancreatic Adenocarcinoma
CA 125
Ovarian Cancer
Calcitonin
MEDULLARY Thyroid Cancer - alone and in MEN2A/2B
CEA
CarcinoEmbryonic Antigen - Very nonspecific
Major associations: Colorectal and Pancreatic Cancers
Minor associations: Gastric, Breast, and Medullary Thyroid Carcinoma
Chromogranin
Neuroendocrine Tumors
PSA
Prostate cancer
P-Glycoprotein
Multidrug Resistant Protein (MDR1)
Adrenocortical Carcinoma
Also expressed in other cancers (Colon, Liver)
Pumps out chemotherapy to make it drug resistant
Vimentin
Mesenchymal Tumors - SARCOMA
Endometrial Carcinoma
Renal Cell Carcinoma
Meningioma
Desmin
Muscle Tumors
Rhabdomyosarcoma
Cytokeratin
Epithelial Tumors
Squamous Cell Carcinoma
GFAP
Neuroglial Tumors - Astrocytes, Schwann Cells, Oligodendrocytes
Astrocytoma, Glioblastoma
Neurofilaments
Neuronal Tumors
Neuroblastoma
Lateral Area of Hypothalamus
Hunger
Destruction –> Anorexia
Stimulated by Ghrelin
Inhibited by Leptin
VMA of Hypothalamus
Satiety Destruction (i.e. Craniopharyngioma) --> Hyperphagia
Stimulated by Leptin