Toxic shock syndrome

Question 1

What is toxic shock syndrome?

Answer 1

Septiceamia from toxin (TSST1) produced by staphylococcus and streptococcus

Straph- exotoxin (TSS toxin 1)
Streptococcus- inflam cascade initiation

aetiology- multisystem inflam response to bacterial exotoxin

RF-
tapons that absord more- infrequent change, overnight use of tampons

still rare -17 per 100000 tampons per year

Question 2

Sx and Ix of toxic shock syndrome

Answer 2

Sx-
fever (high), myalgia, diffuse red patch, D&V, sore throat, headache,
SHOCK

ix- FBC- raiseed WCC, low platelet
UE- impaired renal, LFT, raised CK, CRP
micro- High vaginal swab, Blood cultuure, tampon cultur

Question 3

Mx and complications of toxic shock syndrome

Answer 3

ABC approach and remove tampons
abx- broad spectrum

complications
septic shocl, DIC, ARDS, death

prog- death is 5-15%