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PA30287 > Topical drug delivery > Flashcards

Topical drug delivery Flashcards

1
Q

How thick is the stratum corneum?

A

0.01mm

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2
Q

How thick is the epidermis?

A

0.1mm

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3
Q

How thick is the dermis?

A

1.0mm

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4
Q

What are the ‘bricks’ and ‘mortar’ of the stratum corneum?

A

Bricks=dead keratin filled cells

Mortar=complex lipid mixture

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5
Q

What are the ‘rivets’ holding corneocytes together called?

A

corneodesmosomes

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6
Q

On average how thick is the skin?

A

1mm

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7
Q

What percentage of an adults weight is water?

A

60%

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8
Q

How much water do we lose across the skin per day?

A

200-300mL

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9
Q

When the drug penetrates the skin, what is it then taken up by?

A

Microcirulation

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10
Q

Name 5 ways of assessing the skin bioavailability in vivo in man

A 
Tape stripping
Suction blister
Microdialysis
Biopsy
Blood levels
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11
Q

In general, maximum flux across the skin decreases with increasing what?

A

Molecular weight

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12
Q

Maximum flux increases with what up to a point?

A

Lipophilicity

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13
Q

After the stratum corneum, the drug must cross what to reach micocirculation?

A

Viable dermis and upper dermis

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14
Q

What is the rate determining barrier of the skin?

A

Stratum corneum

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15
Q

What is the skin surface pH?

A

4-5.5

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16
Q

Are ionised or unionised drugs best absorbed across the skin?

A

Unionised

17
Q

Are skin formulations usually high low or neutral pHs?

A

Neutral

18
Q

What is the lag time?

A

Time required to establish linear concentration gradient

19
Q

Transdermal delivery has what kind of kinetics?

A

Flip-flop

20
Q

Describe the kinetics when a drug is given orally?

A

Kinetics of absorption are faster than kinetics of elimination

21
Q

Described the kinetics when a drug is given topically

A

Kinetics of absorption are usually slower than kinetics of elimination. Flip-flop kinetics

22
Q

MEC?

A

Minimum effective concentration

23
Q

MTC?

A

Minimum toxic concentration

24
Q

What are the disadvantages to GTN ointment?

A

Larger dose, slower onset of action

25
Q

What are the advantages to GTN ointment?

A

skin ‘control’, sustained effect

PA30287 (17 decks)

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