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PA30287 > Pressurised metred dose inhalers > Flashcards

Pressurised metred dose inhalers Flashcards

1
Q

pMDIs had over what % of the market sales for disposable inhalation devices before 2000?

A

75%

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2
Q

What are the 5 components that a basic metred dose inhaler consists of?

A 
Drug
Propellant
Aerosol canister
Metering valve
Actuator orifice
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3
Q

For pMDIs are suspensions or solutions preferred for most drugs?

A

Suspensions as they exhibit greater chemical stability

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4
Q

What are the 4 types of physical instability in pMDIs?

A

Rapid flocculation
Bulk separation
Irreversible aggregation
Crystal structure instability

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5
Q

What is the primary role of the adjuvant?

A

Ensure the physical stability of the suspension formulation

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6
Q

What are the commonly used surfactants in CFCs?

A

Sorbitan trioleate
Oleic acid
Soya lecithins

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7
Q

What are the commonly used surfactants in HFAs?

A

Oleic acid
Magnesium stearate
PEG
PVP

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8
Q

What is an exmaple of a typical suspension formulation?

A 
Micronised drug-20-1--micrograms
Surfactant (Oleic acid): 0.1-2%w/w
Propellant (HFA): 10ml
Can size: 100-400 actuations
Metering chamber: 20-200microlitres
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9
Q

What is the logical choice if solubility and stability of the active drug in propellant and co-solvent are adequate?

A

Solution based formulations

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10
Q

The presence of a polar co-solvent can cause what?

A

Corrosion of an aluminium canister

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11
Q

What is a typical solution formulation?

A 
Drug (not micronised)
Ethanol
Saccharine
Flavour-menthol
Antioxidant-ascorbic acid
Propellant- vapour pressure
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12
Q

What is the CFC replacement?

A

HFAs

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13
Q

What is the problem with hydrocarbons as propellants?

A

V.flammable

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14
Q

Is the actuator design more critical with CFCs or HFAs?

A

HFAs

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15
Q

What are the advatages of pMDIs?

A 
Consistent delivery of aerosol dose
Relatively cheap
Moisture resistant
Compact
Available for all drugs
Capital cost for marker entry lower than multiple dose DPIs
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16
Q

What are the disadvantages with pMDIs?

A 
Patient coordination and force required to actuate
 Cold freon effect
Tail off at end of a can
Force of aerosol spray
Varying deposition pattern in airways
High throat deposition
Minimum IP protection for Pharm R&D
17
Q

Why must a pMDI be shaken before use?

A

To mix the drug with propellant

18
Q

How long should a patient hold their breath for upon actuation?

A

5-10seconds

PA30287 (17 decks)

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