Targeted drug delivery 1 Flashcards
Targeted delivery usually refers to what?
Parenteral routes
What are the ideal qualities of TDDs?
- Targets drug to target cell
- Keeps away from non target cell
- Minimises loss of drug
- Protects drug from prem clearance
- Retains drug at target site for period of time
- Facilitates intracellular delivery
- is biocompatible, biodegradable and non antigenic
What are soluble carriers?
Drug covalently attached and released through a chemical reaction
What are particulate carriers?
Drug physically associated with carrier and then released by chemical reaction, diffusion, pH change, temperature or magnetism
What are the 2 types of drug targeting?
Passive
Active
What polymer was attached to the anti-tumour neocarzinostatin (NCS) to make it more hydrophobic to enable dispersion into Lipiodol?
Styrene maleic anhydride (SMA)
What size range are tumour microvessel pores?
100nm to 1.2microns
What macromolecules are effected by the EPR effect?
Polymer conjugates
Micelles
Liposomes
Nanoparticles
What are Stealth liposomes approved for?
AIDS-related Kaposi’s sarcoma
Ovarian cancer
Multiple myeloma
What is PDEPT?
Polymer directed enzyme prodrug therapy. Uses enzymes artificially introduced into the body to convert prodrugs to the active form in the desired location within the body.
What enzymes can be used for prodrug approaches?
B-glucuronidase
Proteases
PSA
Cathepsins
What do hypoxia sensitive drugs rely on ?
Reductive enzymes to generate radical
Tumour environment can be how many pH units lower than normal tissues?
0.5 to 1.0
What does aldoxorubicin do?
Binds to circulating albumin following administration
