Controlled drug delivery 3

Question 1

What controls drug release for responsive DDS?

Answer 1

pH
Chemicals
Enzymes
Ultrasound
Magnetism
Light

Question 2

Changes in ionisation or cleavage of functional groups due to altered pH can affect what?

Answer 2

Sol-gel behaviour

Question 3

What are drug pellets coated in for COLAL colonic drug delivery?

Answer 3

ethylcellulose and ‘glassy’ amylose

Question 4

What are the pros of implantable devices?

Answer 4

Convenience
Compliance
Control
Commercial

Question 5

What are the cons of implantable devices?

Answer 5

Surgery
Failure
Potency
Reactions/compatibility
Commercial

Question 6

What can implants be used for in localised terms?

Answer 6

Ocular
Dental
Contraception
Pain
Vasculature

Question 7

What can implants be used for in long term terms?

Answer 7

Contraception
Pain management
Diabetes
Incontinence
Systemic infection

Question 8

Name two examples of diffusion controlled implants for contraception?

Answer 8

Norplant

Jadelle

Question 9

What is retisert used for?

Answer 9

Chronic noninfectious uveitis

Question 10

What is I-Vation intravitreal implant used for?

Answer 10

Age related macular degeneration
Diabetic macular edema
Glaucoma

Question 11

How long does it take to insert a I-Vation intravitreal implant?

Answer 11

15 minutes

Question 12

How long does a I-Vation intravitreal implant last?

Answer 12

up to 2 years

Question 13

What part of the eye is the I-Vation intravitreal implant placed in?

Answer 13

Sub-conjunctiva

Question 14

What is Medidur used for?

Answer 14

Diabetic Macular Edema

Question 15

What does Medidur do?

Answer 15

Releases a constant amount of drug to the back of the eye for up to 36 months

Question 16

What is Vitrasert used for?

Answer 16

Intraocular ganciclovir for AIDS-related cytomegalovirus retinitis

Question 17

Where is Vitrasert inserted?

Answer 17

Posterior of the eye

Question 18

How long does Vitrasert last?

Answer 18

5 to 8 months

Question 19

What is Ocusert used for?

Answer 19

Elevated intraocular pressure in pilocarpine responsive glaucoma patients

Question 20

What do drug eluting stents limit?

Answer 20

Restenosis

Question 21

What is Viadur used for?

Answer 21

Pain, urinary problems and other symptoms associated with advanced bladder cancer

Question 22

What is Viadur?

Answer 22

Osmotic pump

Question 23

What are Gliadel wafers used for?

Answer 23

treatment of high grade malignant gliomas

Question 24

How long do Gliadel wafers take to erode?

Answer 24

2 to 3 weeks

Question 25

What is SynchroMed infusion pump indicated for?

Answer 25

Intractable pain of malignant or benign origin
Severe chronic pain
Severe spasticity of spinal or cerebral origin
Treatment of cancer

Question 26

What attempts have there been at prolonging residence time?

Answer 26

Floating or swelling in gastric fluid
Sedimentation into gastric folds
Mucoadhesion