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PA30287 > Controlled drug delivery 3 > Flashcards

Controlled drug delivery 3 Flashcards

1
Q

What controls drug release for responsive DDS?

A 
pH
Chemicals
Enzymes
Ultrasound
Magnetism
Light
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2
Q

Changes in ionisation or cleavage of functional groups due to altered pH can affect what?

A

Sol-gel behaviour

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3
Q

What are drug pellets coated in for COLAL colonic drug delivery?

A

ethylcellulose and ‘glassy’ amylose

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4
Q

What are the pros of implantable devices?

A

Convenience
Compliance
Control
Commercial

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5
Q

What are the cons of implantable devices?

A 
Surgery
Failure
Potency
Reactions/compatibility
Commercial
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6
Q

What can implants be used for in localised terms?

A 
Ocular
Dental
Contraception
Pain
Vasculature
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7
Q

What can implants be used for in long term terms?

A 
Contraception
Pain management
Diabetes
Incontinence
Systemic infection
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8
Q

Name two examples of diffusion controlled implants for contraception?

A

Norplant

Jadelle

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9
Q

What is retisert used for?

A

Chronic noninfectious uveitis

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10
Q

What is I-Vation intravitreal implant used for?

A

Age related macular degeneration
Diabetic macular edema
Glaucoma

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11
Q

How long does it take to insert a I-Vation intravitreal implant?

A

15 minutes

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12
Q

How long does a I-Vation intravitreal implant last?

A

up to 2 years

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13
Q

What part of the eye is the I-Vation intravitreal implant placed in?

A

Sub-conjunctiva

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14
Q

What is Medidur used for?

A

Diabetic Macular Edema

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15
Q

What does Medidur do?

A

Releases a constant amount of drug to the back of the eye for up to 36 months

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16
Q

What is Vitrasert used for?

A

Intraocular ganciclovir for AIDS-related cytomegalovirus retinitis

17
Q

Where is Vitrasert inserted?

A

Posterior of the eye

18
Q

How long does Vitrasert last?

A

5 to 8 months

19
Q

What is Ocusert used for?

A

Elevated intraocular pressure in pilocarpine responsive glaucoma patients

20
Q

What do drug eluting stents limit?

A

Restenosis

21
Q

What is Viadur used for?

A

Pain, urinary problems and other symptoms associated with advanced bladder cancer

22
Q

What is Viadur?

A

Osmotic pump

23
Q

What are Gliadel wafers used for?

A

treatment of high grade malignant gliomas

24
Q

How long do Gliadel wafers take to erode?

A

2 to 3 weeks

25
Q

What is SynchroMed infusion pump indicated for?

A

Intractable pain of malignant or benign origin
Severe chronic pain
Severe spasticity of spinal or cerebral origin
Treatment of cancer

26
Q

What attempts have there been at prolonging residence time?

A

Floating or swelling in gastric fluid
Sedimentation into gastric folds
Mucoadhesion

PA30287 (17 decks)

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