Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PA30287 > Controlled drug delivery 2 > Flashcards

Controlled drug delivery 2 Flashcards

1
Q

What kind of polymers are used for diffusion controlled DDS?

A

Water-insoluble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the membrane like for a diffusion controlled reservoir DDS?

A

Non-porous or micro-porous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

For a diffusion controlled matrix DDS does release rate increase or decrease over time?

A

Decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is the release profile of diffusion controlled matrix DDS altered?

A

Using different geometries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the drug dissolved in in a chemically controlled DDS?

A

Polymer solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is the drug released in a chemically controlled DDS?

A

As the polymer breaks down

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What kind of release system is used predominantly for long term implantation?

A

Chemically controlled DDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the production method for chemically controlled DDS?

A 
Compression and melt molding
Solvent casting
Extrusion
Emulsion
Electropinning
3D printing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How do polymeric devices of chemically controlled DDS degrade?

A

Gradual dissolution of the polymer matrix

Degradation of the polymer matrix via chemical or biological processes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are 6 types of natural polymers?

A 
Collagen
Fibrin
Gelatin
Hyaluronan
Chitin/chitosan
Silk
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are 4 types of synthetic polymers?

A

Poly(esters)
Poly(anhydrides)
Poly (ortho esters)
Poly(phosphoesters)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What factors affect polymer degradation rate of chemically controlled DDS?

A 
Chemical structure of polymer
Polymer molecular weight
Presence of low MW compounds
Crystalline vs amorphous polymers
Size and shape
Processing method
Porosity
Site of implantation
Degradation mechanism
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the two types of erosion for chemically controlled DDS?

A

Surface erosion

Bulk erosion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the most common polymers for bulk erosion?

A

Poly(esters)- especially poly(lactic acid) and poly(glycolic acid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the most common polymers for surface erosion?

A

Poly(ortho esters)

Poly(anhydrides)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What can be used to change the release profile of chemically controlled DDS by surface erosion?

A

Geometry

17
Q

What is a pendant system?

A

Polymer backbone with linker to drug. Modify backbone to control water ingress and drug release

18
Q

Electrospinning suspensions and emulsions can reduce what?

A

Burst release

PA30287 (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions