TOLERANCE Pharmacodynamic Tolerance Metabolic Tolerance Tachyphylaxis

Question 0

Pharmacodynamic _____ increases the minimum effective concentration (MEC) of a drug.

Xxxxx

Answer 0

Tolerance

Question 1

• “Metabolic tolerance results from accelerated drug -_____. Metabolic tolerance does not affect the -_____.

Xxxxx

Answer 1

Metabolism

MEC -[metabolic effective concentration]

Question 2

• Pharmacodynamic tolerance results from -______ _____that occur in response to prolonged drug exposure.

Xxxxx

Answer 2

Adaptive changes

Question 3

Key Points:
• When a patient becomes tolerant to a drug, the dosage must be _____to maintain beneficial effects.

Ooooo

Answer 3

Increased