Module 1 Terminology

Question 1

Drug Half Life

Answer 1

The time required for half of a total drug amount to be eliminated from the body.

Question 2

Bioavailability

Answer 2

The fraction or percentage of a drug that reaches the systemic circulation.

Question 3

Hepatic First Pass

Answer 3

The phenomenon by which a drug first passes through the liver for degradation before distribution to the tissue

Question 4

Protein binding

Answer 4

After absorption into the blood and lymph a drug may circulate throughout the body unbound (free drug) or bound to carrier proteins such as albumin.

Question 5

Drug clearance

Answer 5

The most important pharmacokinetic parameter. Determines maintenance dose.

Question 6

Drug elimination

Answer 6

Drug clearance and dose

requirements vary markedly throughout life.

Question 7

Volume of distribution

Answer 7

The volume into which a drug appears to be distributed. Determines loading dose.

Question 8

an unusual adverse or unexpected reaction that does not occur in most people, and is not representative of the known pharmacologic components of a drug.

Answer 8

Idiosyncratic drug reaction

Question 9

a disease or adverse effect caused by medical treatment (in this case a drug).

Answer 9

Iatrogenic effect

Question 10

when substance or drug dependence results in tolerance, withdrawal or both.

Answer 10

Physical dependence

Question 11

a severe allergic reaction to a drug.

Answer 11

Anaphylaxis