Module a pre-test study guide

Question 1

biotransformation of a drug often occurs with
A) Tissue binding in a body compartment.
B) Decreased cardiac output.
C) Hepatic first pass hepatic effect (liver)
D) Protein binding in the bloodstream.

Answer 1

C) Hepatic first pass hepatic effect (liver)

Question 2

A health care provider would use knowledge of a drug’s half life as a factor in determining
A) The precise timing of drug elimination.
B) The dosage and frequency of drug administration.
C) Which brand of a generic drug to mandate
D) The precise timing of drug distribution.

Answer 2

B) The dosage and frequency of drug administration.

Question 3

The intensity of an allergic drug reaction is based on:
 A) First pass effect
 B) drug dosage
 C) immune system sensitization
 D) age and gender

Answer 3

C) immune system sensitization

Question 4

Intestinal transit time increases (ie. takes longer to leave the gut) during pregnancy due to a decrease of tone and motility. The clinician would expect this to have what effect on the pharmacokinetics of an oral medication taken by a pregnant woman?
 A) Increased drug absorption
 B) Decreased protein binding
 C) Decreased drug distribution
 D) Increased biotransformation

Answer 4

A) Increased drug absorption

Question 5

Which of the following components of pharmacokinetics is least affected by aging?
 A) Excretion
 B) Distribution
 C) Absorption
 D) Metabolism

Answer 5

C) Absorption

Question 6

A drug is classified as Pregnancy category D. What does this mean, and what is a good example?
A) Proven risk of fetal harm. Benefit despite the risks is rare (but may occur with hard to treat conditions or diseases in pregnancy). Ex: Paxil.
B) Controlled studies in women have failed to demonstrate a risk to the fetus in the first trimester. Ex. Lexapro
C) Either studies in animals have revealed adverse effects on the fetus, but no controlled studies in women have been reported, or studies in women and animals are not available. Ex: Zoloft
D) Either animal reproduction studies have not demonstrated fetal risk but no controlled studies in pregnant women have been reported, or animal studies have shown an adverse effect that was not confirmed in controlled studies in women during the first trimester. Ex: Prozac

Answer 6

A) Proven risk of fetal harm. Benefit despite the risks is rare (but may occur with hard to treat conditions or diseases in pregnancy). Ex: Paxil.

Question 7

The federal agency responsible for monitoring the development of a new drug is the
 A) National Institutes of Health (NIH)
 B) United States Pharmacopeia (USP)
 C) Drug Enforcement Agency (DEA)
 D) Food and Drug Adminsitration (FDA)

Answer 7

D) Food and Drug Adminsitration (FDA)

Question 8

With aging, which of the following statements is true regarding drug absorption?
A) stomach pH may increase
B) blood flow may increase
C) GI tract transit time may decrease
D) The mass of organ tissue will increase

Answer 8

A) stomach pH may increase

Question 9

The majority of drugs are thought to act by which of the following mechanisms?
A) Attaching to the receptors on cell surfaces.
B) Altering protein synthesis in the cell.
C) Changing the DNA structure in cells.
D) Promoting cell growth.

Answer 9

A) Attaching to the receptors on cell surfaces.

Question 10

Teratogen-induced gross malformations result from exposure during which period of gestational age?
 A) Weeks 3-8
 B) Weeks 7-12
 C) Weeks 10-15
 D) Weeks 1-3

Answer 10

A) Weeks 3-8